Andrea Corsinotti　（国際テニュアトラック助教）

	氏名 Name	Andrea Corsinotti
	所属 Affiliation	医学医療系 Faculty of Medicine
	メンター Mentor	高橋 智 教授 Professor Satoru Takahashi
	派遣先 Host Institution	MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
	Mentor	Professor Ian Chambers

Key wards：Pluripotent states, Embryonic stem cells, Transcription factors, Heterogeneity, CRISPR/Cas9

専門：Genetic approaches for the understanding of pluripotent state transitions in embryonic stem cells and during development.

研究概要／Summary

My research interests focus on the understanding of how pluripotency is maintained in mouse embryonic stem cells and how the transitions between pluripotent states are regulated during early development. I am particularly interested in the regulation of key pluripotency transcription factors such as Oct4, Nanog and Sox2. To achieve these aims I am using the CRISPR/Cas9 technology to develop pluripotent cell lines in which the genes encoding for these transcription factors or their regulatory sequences have been engineered.

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