Keyword
Emerging infectious diseases, Avian influenza, SARS-CoV-2, Antiviral drugs
研究テーマ
- Molecular Virology
研究ハイライト
Major Scientific Interests of the Group
The research aim of this group is to understand the molecular mechanism of replication and pathogenicity of animal viruses such as influenza virus and SARS-CoV-2. The structure and function of virus-encoded factors and host cell-derived factors involved in virus replication are being studied at the atomic, molecular and body levels. We also focus on the host innate immune responses against virus infection.
Projects for Regular Students in Doctoral or Master’s Programs
1) Identification and characterization of novel factors in virus replication
2) Molecular mechanism of host innate immune responses to virus infection
3) Control of virus infections through development of novel anti-viral drugs
Study Programs for Short Stay Students (one week – one trimester)
1) Molecular mechanism of host factors involved in influenza virus replication
2) Action mechanism of anti-virus drugs
研究の応用・展望
- Our projects focus on the molecular mechanism of replication and pathogenicity of emerging infectious diseases. Our findings will contribute the developments of antivirals and new diagnosis system. We also aim to establish animal models to understand the pathogenicity of emerging viruses.
文献・知財・作品
- 1) Lee S, Ishitsuka A, Noguchi M, Hirohama M, Fujiyasu Y, Petric PP, Schwemmle M, Staeheli P, Nagata K, Kawaguchi A. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Science Immunol., 2019; 4(40): eaau4643.
- 2) Lee S, Hirohama M, Noguchi M, Nagata K, Kawaguchi A. Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through the type I interferon signaling pathway in a mutually exclusive manner. J. Virol., 2018; 92(14): e00396-18.
- 3) Kawaguchi A, Hirohama M, Harada Y, Osari S, Nagata K. Influenza virus induces cholesterol-enriched endocytic recycling compartments for budozone formation via cell cycle-independent centrosome maturation. PLoS Pathog.,2015; 11(11): e1005284.
http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/
90532060
医学医療系
Ph.D. Program in Human Biology, School of Integrative and Global Majors,
Department of Infection Biology, Faculty of Medicine
Other Faculty Member
Assistant Professor Kohsuke KATO
Assistant Professor Takeshi SEKIYA
Assistant Professor Yuji Funakoshi