Keyword
Limited sample analysis, protocol standardization and automation
研究テーマ
- Genome Biology
研究ハイライト
Major Scientific Interests of the Group
The main research interests in our group is genomics and epigenomics in space life science and clinical research, with particular focus on development of technologies for limited sample analysis. We also collaborate with clinicians and industry partners to implement our methods to personalized medicine and automated laboratory testing using AI and robotics.
Projects for Regular Students in Doctoral or Master’s Programs
1) Clinical sample analysis using chromatin immunoprecipitation combined with 2nd generation
sequencing (ChIPseq) and RNAseq, data analysis and validation of potential disease biomarkers.
2) Genomics and epigenomics analysis in space research projects
Study Programs for Short Stay Students (one week – one trimester)
1) Access to genomics databases, integrative analysis of regulatory regions, gene expression and
genetic variations.
2) Genomics and epigenomics assays, chromatin immunoprecipitation, RNA assays and genotyping.
研究の応用・展望
- MM is Senior Research Fellow of Genome Science Research Center, LSI Medience Corporation through cross-appointment system of University of Tsukuba, and Research Advisor of Robotic Biology Institute Inc.
文献・知財・作品
- Rutter L, Barker R, Bezdan D, Cope H, Costes SV, Degoricija L, Fisch KM, Gabitto MI, Gebre S, Giacomello S, Gilroy S, Green SJ, Mason CE, Reinsch SS, Szewczyk NJ, Taylor DM, Galazka JM, Herranz R, Muratani M. A New Era for Space Life Science: International Standards for Space Omics Processing. Patterns. 1(9):100148, 2020.
- Muratani M, Deng N, Ooi WF, Lin SJ, Xing M, Xu C, Qamra A, Tay ST, Malik S, Wu J, Lee MH, Zhang S, Tan LL, Chua H, WongWK, Ong HS, Ooi LL, Chow PK, ChanWH, Soo KC, Goh LK, Rozen S, Teh BT, Yu Q, Ng HH, Tan P. Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. Nat Commun. 5:4361, 2014.
http://www.md.tsukuba.ac.jp/basic-med/genome/
50730199
医学医療系
Limited sample analysis, protocol standardization and automation