Stem Cell Therapy Major Scientific Interests of the Group. | 山﨑 聡 | 筑波大学研究者カタログ

代表者 : 山﨑 聡    中核研究者 : 水谷 英二  全 孝静  

Keyword

Stem Cell signaling, Stem Cell regulation, Cell Transplantation, Gene Editing, Gene Therapy

研究テーマ

  • Stem Cell Therapy Major Scientific Interests of the Group.
  • Our Group aims is creative research of stem cell for clinical application.

研究ハイライト

Major Scientific Interests of the Group

1) Elucidation of regulatory mechanisms underlying self-renewal and differentiation of stem cells.

(Especially focusing on blood stem cells.)

2) A study on the efficient utilization of intra-placental injection in a murine model.

3) Analysis of mammalian embryonic development mechanism using developmental engineering

techniques

Projects for Regular Students in Doctoral or Master’s Programs Regulation of stem cell self-renewal and differentiation.

1) Generation of allogeneic/xenogeneic hematopoietic chimera mouse model

2) Analysis of reprogramming mechanism using cloned embryos and development of new embryo

manipulation technology

Study Programs for Short Stay Students (one week – one trimester)

1) Understanding of ex vivo somatic cells expansion.

2) Practice and understanding of a mouse model of in utero transplantation

3) Practice of embryo manipulation using a micromanipulator

研究の応用・展望

  • Our laboratory can test capabilities of self-renewal and multilineage differentiation at single cell levels using either in vitro or in vivo assays. We believe that HSC research will eventually make great contributions to the development of safe and efficacious regenerative medicine and gene therapy.

文献・知財・作品

  • Long-term ex vivo expansion of mouse hematopoietic stem cells. Wilkinson AC, Ishida R, Nakauchi H,Yamazaki S. Nat Protoc. 2020 Feb;15(2):628-648. doi: 10.1038/s41596-019-0263-2. Epub 2020 Jan 8.
  • Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Wilkinson AC,Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M,Nakauchi H, Yamazaki S. Nature. 2019 Jul;571(7763):117-121. doi: 10.1038/s41586-019-1244-x. Epub 2019 May29
  • Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation. Taya Y,Ota Y, Wilkinson AC, Kanazawa A, Watarai H, Kasai M, Nakauchi H, Yamazaki S. Science. 2016 Dec 2;354(6316):1152-1155. doi: 10.1126/science.aag3145. Epub 2016 Oct 20.

https://ura.sec.tsukuba.ac.jp/unit-members?kid=50625580

50625580

医学医療系

Faculty of Medicine, Laboratory of Stem Cell Therapy, University of Tsukuba

Other Faculty Members

Associate Professor Eiji Mizutani

Assistant Professor Jeon Hyojung