Keyword
Pediatric Disorders, Diagnosis, Genetic Disorders, Gene Therapy
研究テーマ
- Pediatrics
- Growth, Development and Child Health
研究ハイライト
Major Scientific Interests of the Group
Physiologic and pathologic processes of growth and development in terms of molecular mechanism in
embryogenesis, differentiation, apoptosis and regeneration. Development of methods to improve
human health and control diseases on the basis of the above results.
Projects for Regular Students in Doctoral or Master’s Programs
1) Molecular mechanism of diseases of children.
2) Functional and quantitative analysis of the development of children with and without diseases.
3) Establishment of novel gene therapy.
Study Programs for Short Stay Students (one week – one trimester)
1) Surface marker analysis of peripheral blood cells, and use of flow-cytometer for molecular functional analysis.
2) Genetic analysis of diseases of children.
3) Functional and quantitative analysis of child development.
4) Culture of stem cells and functional analysis of cord blood cells.
5) In vivo analysis using gene knockout mice
研究の応用・展望
- To Clarify the Molecular Mechanism of Normal Growth and Development. Whole Genome Analysis and Development of New Diagnostic System including Newborn Screening for Early Diagnosis of Pediatric Disorders. Use of National Database, Molecular Genetics and Immunology to Clarify Pathophysiology of Pediatric Disorders.
文献・知財・作品
- Quantitative assessment of fine motor skills in children using magnetic sensors. Enokizono T, Ohto T, Tanaka M, Maruo K, Sano Y, Kandori A, Takada H. Brain Dev. 2020 Jun;42(6):421-430.
- Utilization of a novel Sendai virus vector in ex vivo gene therapy for hemophilia A. Yamaki Y, Fukushima T, Yoshida N, Nishimura K, Fukuda A, Hisatake K, Aso M, Sakasai T, Kijima-Tanaka J, Miwa Y, Nakanishi M, Sumazaki R, Takada H. Int J Hematol. 2021 Apr;113(4):493-499.
- Novel ACOX1 mutations in two siblings with peroxisomal acyl-CoA oxidase deficiency. Morita A, Enokizono T, Ohto T, Tanaka M, Watanabe S, Takada Y, Iwama K, Mizuguchi T, Matsumoto N, Morita M, Takashima S, Shimozawa N, Takada H. Brain Dev. 2021 Mar;43(3):475-481.
https://ura.sec.tsukuba.ac.jp/unit-members?kid=70294931
70294931
医学医療系
Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba
Other Faculty Members
Associate Professor : Yayoi Miyazono, Tatsuyuki Ohto,
Lecturer : Hiroko Fukushima, Ryoko Suzuki, Manabu Tagawa, Atsushi Iwabuchi, Taku Murakami, Yu Kanai