Pharmacokinetic and pharmacogenetic research to support precision dosing in clinical practice | 本間 真人 | 筑波大学研究者カタログ

代表者 : 本間 真人    中核研究者 : 土岐 浩介  

Keyword

Drug-drug interactions, Pharmacogenetics, Therapeutic drug monitoring

研究テーマ

  • Pharmacokinetic and pharmacogenetic research to support precision dosing in clinical practice

研究ハイライト

Major Scientific Interests of the Group

Pharmacokinetic and pharmacogenetic analyses for evaluating drug disposition, drug-drug interactions,

drug efficacy, and drug toxicity in relation to drug metabolizing enzymes and drug transporters.

Pharmacokinetic evaluation of Kampo-medicine (herbal remedy).

Projects for Regular Students in Doctoral or Master’s Programs

1) Pharmacokinetic analysis and therapeutic drug monitoring of anti-neoplastic agents, antiarrhythmic

agents, thrombopoietin receptor agonist and immunosuppressive agents

2) Pharmacogenetic analysis of anti-arrhythmic agents and immunosuppressive agents

3) Evaluation of adverse effect caused by Kampo-medicines containing licorice

Study Programs for Short Stay Students (one week – one trimester)

1) Development of assay methods for monitoring blood drug concentration

2) Evaluation of genetic polymorphisms associated with drug metabolism and transport

研究の応用・展望

  • Dose adjustment using the measurement of blood drug concentration in drug therapy.
  • Effective utilization of pharmacogenetic information for dose individualization.

文献・知財・作品

  • Doki K, Shirayama Y, Sekiguchi Y, Aonuma K, Kohda Y, Homma M. Optimal sampling time and clinical implication of the SCN5A promoter haplotype in propafenone therapeutic drug monitoring. Eur J Clin Pharmacol. 74: 1273-1279, 2018.
  • Ohgami M, Kaburagi T, Kurosawa A, Doki K, Shiozawa T, Hizawa N, Homma M. Effects of Proton Pump Inhibitor Coadministration on the Plasma Concentration of Erlotinib in Patients With Non-Small Cell Lung Cancer. Ther Drug Monit. 40: 699-704, 2018.
  • Ohgami M, Bando H, Ishiguro H, Tsuda M, Toriguchi N, Aogi K, Toi M, Masuda N, Mitsuhashi S, Kurosawa A, Homma M. Effect of dose timing on the blood concentration of lapatinib in patients with breast cancer. Ann Oncol. 28: 2888-2889, 2017.

http://www.md.tsukuba.ac.jp/clinical-med/pharmsci/

90199589

医学医療系

Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba

 

Other Faculty Members

Associate Professor Kosuke Doki