Keyword
VLP vaccine, Influenza universal vaccine, Paramyxoviruses
研究テーマ
- Environmental Microbiology
研究ハイライト
Major Scientific Interests of the Group
The aim of our group is to understand the host-pathogen interactions. We are analyzing molecular
mechanism of the pathogenicity of paramyxoviruses. We are also interested in applied science. We
are developing edible vaccines using virus-like particles (empty virion without genome) of small
non-enveloped viruses produced in plants.
Projects for Regular Students in Doctoral or Master’s Programs
1) Manipulation of negative-stranded viruses
2) Generation of edible vaccines
Study Programs for Short Stay Students (one week – one trimester)
1) Rescue of recombinant virus from cloned cDNA
2) Expression of virus proteins in E. coli.
研究の応用・展望
- Our goal is making VLP vaccines and influenza universal vaccines for human and animal use.
文献・知財・作品
- Takeuchi K, Nagata N, Kato SI, Ami Y, Suzaki Y, Suzuki Y, Sato Y, Tsunetsugu-Yokota Y, Mori K, Van Nguyen N, Kimura H, Nagata K. Wild-type measles virus with the hemagglutinin protein of the Edmonston vaccine strain retains wild-type tropism in macaques. J Virol. 2012; 86:3027-3037. (corresponding author)
- Kubota M, Takeuchi K, Watanabe S, Ohno S, Matsuoka R, Kohda D, Nakakita SI, Hiramatsu H, Suzuki Y,Nakayama T, Terada T, Shimizu K, Shimizu N, Shiroishi M, Yanagi Y, Hashiguchi T. Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus. Proc Natl Acad Sci U S A. 2016; 113(41):11579-11584.(corresponding author)
- Takada M, Matsuura R, Kokuho T, Tsuboi T, Kameyama KI, Takeuchi K. Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene. J Virol Methods. 2017, 249:25-30.(corresponding author)
http://www.md.tsukuba.ac.jp/basic-med/takeuchi/index.html
00192162
医学医療系
Department of Infection Biology, Division of Biomedical Science, Faculty of Medicine