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金子 新

Kaneko, Shin

iPS細胞研究所 増殖分化機構研究部門 免疫再生治療分野 , 教授
Regenerative Immunotherapy (Shin Kaneko Lab), Dept. Cell Growth and Differentiation, Center for iPS cell Research and Application (CiRA) , Professor

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  1. 1. IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors. Akihiro Ishikawa; Masazumi Waseda; Tomoko Ishii; Yohei KawaiShin Kaneko
      Molecular therapy : the journal of the American Society of Gene Therapy (2026) Semantic Scholar
  2. 2. Feeder-free generation of CD4 single-positive helper T cells from human iPSCs via stage-specific modulation of Notch and TCR Signaling. Yohei Kawai; Shin Kaneko
      Molecular therapy : the journal of the American Society of Gene Therapy 34: 2725 (2026) Semantic Scholar
  3. 3. Stress-induced CXCL13 regulates pancreatic exocrine homeostasis, age-related chronic inflammation, and cancer progression. Masahiro Yoshida; Kenichiro Furuyama; Keisuke Sumide; Masashi Horiguchi (+13 著者) Yoshiya Kawaguchi
      Science advances 12: eadu7865 (2026) Semantic Scholar
  4. 4. Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny. Jing Zhang; Keisuke Sumide; Keitaro Kanie; Akihiro Ishikawa (+3 著者) Shin Kaneko
      Regenerative therapy 31: 101060 (2026) Semantic Scholar
  5. 5. Chimeric synthetic T cell receptor and antigen receptor receptors enable high-sensitivity T cell receptor-negative CD8αβ-CD3-positive T-cell development from human-induced pluripotent stem cells. Chaoqi Zhang; Michael Rassner; Yohei Kawai; Qingyi Guo (+2 著者) Shin Kaneko
      Cytotherapy 28: 102001 (2026) Semantic Scholar
  6. 6. Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells. Sara Shiina; Tatsuki Ueda; Shoichi Iriguchi; Yasushi UemuraShin Kaneko
      Communications biology (2026) Semantic Scholar
  7. 7. Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control. Qingyi Guo; Chaoqi Zhang; Bo Wang; Shoichi Iriguchi (+4 著者) Shin Kaneko
      Inflammation and regeneration 46: 4 (2026) Semantic Scholar
  8. 8. Development of a novel in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes. Ryota Kobayashi; Katsunori Sasaki; Ryoko Matsuyama; Koichi Saito (+3 著者) Shin Kaneko
      Genes and environment : the official journal of the Japanese Environmental Mutagen Society 47: 24 (2025) Semantic Scholar
  9. 9. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Keitaro Kanie; Takeshi Ito; Genzo Iguchi; Ryusaku Matsumoto (+8 著者) Yutaka Takahashi
      Nature communications 16: 7900 (2025) Semantic Scholar
  10. 10. Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin. Yuta Mishima; Shintaro Okada; Akihiro Ishikawa; Bo Wang (+3 著者) Shin Kaneko
      Regenerative therapy 28: 292 (2025) Semantic Scholar
  11. 11. Current Landscape of Adoptive Cell Therapy and Challenge to Develop "Off-The-Shelf" Therapy for Hepatocellular Carcinoma. Seung Kak Shin; Yuta Mishima; Yoonseok Lee; Oh Sang Kwon (+2 著者) Shin Kaneko
      Journal of gastroenterology and hepatology 40: 791 (2025) Semantic Scholar
  12. 12. Non-human primate preclinical model revealed the feasibility and short-term safety of iPSC-derived innate-like T cells in autologous transplantation. Yasuyuki Miyake; Shoichi Iriguchi; Ai Kawana-Tachikawa; Shuichi Kitayama (+6 著者) Shin Kaneko
      Frontiers in immunology 16: 1653275 (2025) Semantic Scholar
  13. 13. Human iPSC-derived CD4+ Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model. Hisashi Yano; Keiko Koga; Takayuki Sato; Tokuyuki Shinohara (+7 著者) Shin Kaneko
      Cell stem cell 31: 795 (2024) Semantic Scholar
  14. 14. A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism. Shin-Ichiro Takayanagi; Sayaka Chuganji; Masahiro Tanaka; Bo Wang (+14 著者) Shin Kaneko
      Communications biology 7: 685 (2024) Semantic Scholar
  15. 15. Downregulating the immune synapses of iPSC-derived T cells to escape the NK cell-mediated killing(タイトル和訳中) 張 静; 王 博; 蟹江 慶太郎; 吉田 宗弘金子 新
      日本がん免疫学会総会・日本バイオセラピィ学会学術集会総会合同大会プログラム・抄録集 28回・37回: 127 - 127 (2024)
  16. 16. Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy. Sota Kurihara; Akihiro Ishikawa; Shin Kaneko
      Inflammation and regeneration 44: 20 (2024) Semantic Scholar
  17. 17. Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8αβ+ T cells targeting multiple myeloma. Jooeun Bae; Shuichi Kitayama; Zach Herbert; Laurence Daheron (+10 著者) Kenneth C Anderson
      Blood 143: 895 (2024) Semantic Scholar
  18. 18. Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system. Masahiro Tanaka; Yoshihiro Iwamoto; Bo Wang; Eri Imai (+2 著者) Shin Kaneko
      Regenerative therapy 27: 104 (2024) Semantic Scholar
  19. 19. Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid culture. Yoshitaka Ishiguro; Shoichi Iriguchi; Shinya Asano; Tokuyuki Shinohara (+5 著者) Shin Kaneko
      Frontiers in immunology 14: 1303713 (2023) Semantic Scholar
  20. 20. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity Alessia Gravina; Grigol Tediashvili; Yueting Zheng; Kumiko A. Iwabuchi (+6 著者) Tobias Deuse
      Cell Stem Cell 30: 1538 (2023) Semantic Scholar
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  1. 1. In Vitro Detection of Cellular Adjuvant Properties of Human Invariant Natural Killer T Cells Rong Zhang; Shuichi Kitayama; Tianyi Liu; Norihiro Ueda; Yumi Tokumitsu; Hiroaki Mashima; Hideki Ohdan; Shin Kaneko; Yasushi Uemura (担当:分担執筆)
    Humana Press Inc. 2019年
  2. 2. In Vitro Differentiation of T Cells: From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Shoichi Iriguchi; Shin Kaneko (担当:分担執筆)
    Humana Press Inc. 2019年
  3. 3. Differentiating CD8αβ T Cells from TCR-Transduced iPSCs for Cancer Immunotherapy Atsutaka Minagawa; Shin Kaneko (担当:分担執筆)
    Humana Press Inc. 2019年
  4. 4. In Vitro Differentiation of T Cells: From Nonhuman Primate-Induced Pluripotent Stem Cells Shoichi Iriguchi; Shin Kaneko (担当:分担執筆)
    Humana Press Inc. 2019年
  5. 5. In Vitro Differentiation of T Cell: From CAR-Modified T-iPSC Tatsuki Ueda; Shin Kaneko (担当:分担執筆)
    Humana Press Inc. 2019年
  6. 6. Redifferentiation of Adaptive Naïve-Like CTL from T-Cell-Derived iPSC Yohei Kawai; Shin Kaneko (担当:分担執筆)
    Humana Press Inc. 2019年

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