Keyword
nutrition, genome, transcription, in vivo imaging, diabetes, aging
研究テーマ
- Nutrigenomics, Diabetes and Endocrinology
- Laboratory Medicine
研究ハイライト
Major Scientific Interests of the Group
The scope of our group is to elucidate how nutritional signals regulate gene expression and adapt individuals to their nutritional environment, using original methods to directly analyze the interaction between nutritional signals and the genome in animal bodies.
Projects for Regular Students in Doctoral or
Master’s Programs
1) Identify a transcription factor complex bridging nutritional signals and the genome
2) Find key enhancers controlling nutrient flows using CRISPR-Cas9 genome editing and CRISPRi techniques
研究の応用・展望
- Figure out how the genome is read to control nutrient flows, why foods can make us both healthy and sick, and how fasting and time-restricted feeding extends our lifespan. Finally establish the royal road to health and well-being.
- Be a builder.
文献・知財・作品
- Yahagi N, Takeuchi Y. Genome-wide screening of upstream transcription factors using an expression library. F1000Research 10:51, 2021.
- Ishizu T, Seo Y, Namekawa M, Murakoshi N, Ieda M, Kawakami Y. Left Ventricular Longitudinal Strain as a Marker for Point of No Return in Hypertensive Heart Failure Treatment. J Am Soc Echocardiogr 33:226-233, 2020.
- Shono A, Kondo M, Hoshi S, Okubo R, Yahagi N. Cost-effectiveness of a new opportunistic screening strategy for walk-in fingertip HbA1c testing at community pharmacies in Japan. Diabetes Care 41:1218-1226, 2018.
- Piao X, Yahagi N, Takeuchi Y, Aita Y, et al. A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes. FEBS Lett 592:422-433, 2018.
- Takeuchi Y, Yahagi N, Aita Y, et al. KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting. Cell Rep 16:2373-86, 2016.
https://plaza.umin.ac.jp/nutrigenomics/
Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba
医学医療系
Other Faculty Members
Professor, Yasushi Kawakami
Lecturer, Kazumasa Isobe
Lecturer, Takayasu Kato
Assistant Professor, Tomoko Machino
Assistant Professor, Yoshinori Takeuchi
Assistant Professor, Yuichi Aita