熊谷 嘉人
Kumagai, Yoshito
九州大学大学院薬学研究院 , 特任教授 Graduate School of Pharmaceutical Sciences , Specially Appointed Professor
http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
http://www.md.tsukuba.ac.jp/environmental_medicine/kibanS2/index.html
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1.
Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.
Akiyuki Nishimura; Seiryo Ogata; Xiaokang Tang; Kowit Hengphasatporn (+11 著者) Motohiro Nishida
Nature communications 16: 276 (2025)
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2.
Epigenetic Regulation of CXC Chemokine Expression by Environmental Electrophiles Through DNA Methyltransferase Inhibition
Tomoki Tsuchida; Sho Kubota; Shizuki Kamiuezono; Nobumasa Takasugi (+2 著者) Takashi Uehara
International Journal of Molecular Sciences (2024)
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3.
Alteration of gene levels in fetal brain by prenatal exposure to methylmercury, copper, and their combination
Sato Kensuke; Nakano Ryota; Yamazaki Yoshitaka; Isobe Hikaru (+3 著者) Kumagai Yoshito
Fundamental Toxicological Sciences 11: 131 (2024)
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4.
Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor
Abiko, Yumi; Taguchi, Keiko; Hisamori, Miwa; Hiyoshi-Arai, Kyoko (+3 著者) Kumagai, Yoshito
Chemical research in toxicology 35: 1425 (2022) Semantic Scholar
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5.
Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs
Kumagai, Yoshito
Biological and Pharmaceutical Bulletin 45: 968 (2022) Semantic Scholar
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6.
Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome
Akiyama, Masahiro; Shinkai, Yasuhiro; Yamakawa, Hiroto; Kim, Yun-GiKumagai, Yoshito
Chemosphere 299: 134374 (2022) Semantic Scholar
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7.
Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan
Horai, Sawako; Abiko, Yumi; Unoki, Takamitsu; Shinkai, Yasuhiro (+3 著者) Kumagai, Yoshito
Chemosphere 295: 133833 (2022) Semantic Scholar
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8.
A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones
Luong; Nho Cong; Abiko, Yumi; Aoki, HanakoKumagai, Yoshito
Biological & pharmaceutical bulletin 45: 798 (2022) Semantic Scholar
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9.
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species
Uchiyama, Jun; Akiyama, Masahiro; Hase, Koji; Kumagai, YoshitoKim, Yun-Gi
Cell reports 38: 110479 (2022) Semantic Scholar
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10.
Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Liu, Jun; Kasai, Shuya; Tatara, Yota; Yamazaki, Hiromi (+13 著者) Itoh, Ken
International Journal of Molecular Sciences 23: 3201 (2022) Semantic Scholar
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11.
Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys247
Abiko, Yumi; Eiko, Yoshida; Kumagai, Yoshito
Fundamental Toxicological Sciences 9: 1 (2022) Semantic Scholar
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12.
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain
Unoki, Takamitsu; Akiyama, Masahiro; Shinkai, Yasuhiro; Kumagai, YoshitoFujimura, Masatake
The Journal of toxicological sciences 47: 31 (2022) Semantic Scholar
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13.
Redox-dependent internalization of the purinergic P2Y receptor limits colitis progression
Nishiyama, Kazuhiro; Nishimura, Akiyuki; Shimoda, Kakeru; Tanaka, Tomohiro (+10 著者) Nishida, Motohiro
Science signaling 15: eabj0644 (2022) Semantic Scholar
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14.
Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells
Takahashi, Musubu; Kubota, Ayaka; Fujie, Tomoya; Shinkai, Yasuhiro (+4 著者) Kaji, Toshiyuki
BPB Reports 4: 175 (2021) Semantic Scholar
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15.
Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways
Takahashi, Musubu; Fujie, Tomoya; Nakano, Tsuyoshi; Hara, Takato (+5 著者) Kaji, Toshiyuki
International journal of molecular sciences 22: 11762 (2021) Semantic Scholar
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16.
The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
Abiko, Yumi; Katayama, Yusuke; Zhao, Wenyang; Horai, Sawako (+1 著者) Kumagai, Yoshito
SCIENTIFIC REPORTS 11: 17598 (2021) Semantic Scholar
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17.
Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation
Wang, Chen; Okita, Yukari; Zheng, Ling; Shinkai, Yasuhiro (+5 著者) Kato, Mitsuyasu
Cancer science 112: 4187 (2021) Semantic Scholar
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18.
Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells
Abiko, Yumi; Kurosawa, Kohki; Yamakawa, Hiroto; Kumagai, Yoshito
The Journal of toxicological sciences 46: 177 (2021) Semantic Scholar
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19.
Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor
Nakahara, Kengo; Hamada, Kyohei; Tsuchida, Tomoki; Takasugi, Nobumasa (+4 著者) Uehara, Takashi
The Journal of biological chemistry 296: 100524 (2021) Semantic Scholar
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20.
Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota
Seki, Natsumi; Akiyama, Masahiro; Yamakawa, Hiroto; Hase, Koji (+1 著者) Kim, Yun-Gi
The Journal of toxicological sciences 46: 91 (2021) Semantic Scholar
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1.
Arsenic Contamination in Asia
Kumagai, Yoshito; Yumi, Abiko
(担当:分担執筆, 範囲:Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic)
Springer, Singapore 2018年12月 (ISBN: 9789811325649)
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2.
RSSによる環境中親電子物質の解毒代謝
熊谷嘉人
(担当:分担執筆, 範囲:RSSによる環境中親電子物質の解毒代謝)
2015年4月
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3.
実験医学「活性酸素・ガス状分子による恒常性制御と疾患」
熊谷,嘉人
(担当:分担執筆, 範囲:環境中親電子リガンドの細胞内侵入とそれに伴うシグナル伝達の模倣および攪乱.)
2012年10月
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4.
細胞工学「活性酸素シグナル制御とレドックスホメオスタシス」
熊谷,嘉人
(担当:分担執筆, 範囲:GAPDHの功罪)
2012年2月
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5.
地球規模におけるヒ素汚染の現状
安孫子, ユミ; 熊谷, 嘉人
(担当:分担執筆, 範囲:地球規模におけるヒ素汚染の現状)
2010年7月
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6.
分子予防環境医学. 分子予防環境医学研究会編.
熊谷嘉人
(担当:分担執筆, 範囲:Nrf2と解毒、酸化ストレス)
本の泉社 2010年1月
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7.
実験医学増刊号
熊谷,嘉人
(担当:分担執筆, 範囲:親電子シグナル伝達)
2009年9月
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8.
酸化ストレスの原因となるディーゼル排出微粒子成分.
熊谷嘉人
(担当:分担執筆, 範囲:酸化ストレスの原因となるディーゼル排出微粒子成分.)
医歯薬出版 2005年1月
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9.
予防医学事典. 松島綱治ら編.
熊谷嘉人
(担当:分担執筆, 範囲:特定化学物質)
朝倉書店 2005年1月
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10.
Molecular Medicine. 末松誠編.
石井哲郎; 伊東健; 熊谷嘉人
(担当:分担執筆, 範囲:Nrf2による酸化ストレス感知と分子応答.)
中山書店 2003年1月
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11.
The Lung Perspective. 谷口直之編.
石井哲郎; 熊谷嘉人
(担当:分担執筆, 範囲:ディーゼル排出微粒子と酸化ストレス防御蛋白質.)
メディカルレビュー社 2002年1月
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12.
社会医学事典. 高野健人ら編.
熊谷嘉人
(担当:分担執筆, 範囲:内分泌撹乱化学物質)
朝倉書店 2002年1月
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13.
衛生薬学新論. 井上圭三ら編.
熊谷嘉人
(担当:分担執筆, 範囲:環境衛生)
南山堂 2001年1月
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14.
Psychopharmacology, Toxicology, and abuse. Cho AK and Segal DS edt,
Cho, AK; Kumagai, Y
(担当:分担執筆, 範囲:Metabolism of amphetamine and other arylisopropylamines. in Amphetamine and its analog)
Academic Press 1994年1月
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15.
フリーラジカルの臨床. 大柳善彦、吉川敏一編.
市ノ瀬孝道; 熊谷嘉人; 嵯峨井勝
(担当:分担執筆, 範囲:ディーゼル排出微粒子による喘息様病態の発症)
1994年1月
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16.
National Institute on Drug Abuse Monograph
Cho,AK; Hiramatsu,M; Kumagai,Y; Patel,N
(担当:分担執筆, 範囲:Pharmacokinetic approach to the study of durg action and toxicology)
1992年1月
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17.
Studies on a novel metabolic parthway of morphine in quinea pig
熊谷, 嘉人
1988年3月
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281.
活性イオウ分子産生酵素シスタチオニンβシンターゼによる親電子シグナル伝達系の制御
新開泰弘; 吉田映子; Bruce,A. FREEMAN; 西田基宏; 澤,智裕; 赤池孝章; 熊谷,嘉人
第41回日本毒性学会学術年会 2014年7月
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282.
転写因子Nrf2の活性化を生じるCoriandrum sativum L.葉抽出物に含有される脂肪族親電子物質の実態解明
安孫子ユミ; 溝河真衣; 熊谷,嘉人
第41回日本毒性学会学術年会 2014年7月
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283.
Role of reactive sulfur species in detoxification of methylmercury: Phase zero reaction for electrophile trapping and detoxification.
Kumagai,Yoshito
8th International Nitric Oxide Conference & 6th International Nitrite/Nitrate Conference 2014年6月
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284.
環境中親電子物質のケミカルバイオロジー: 化学修飾を介したシグナル伝達の変動および毒性発現とそれらを制御する活性イオウ分子.
熊谷,嘉人
東北薬科大学創薬研究センターシンポジウム 2014年6月 招待有り
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285.
Bismethylmercury sulfideアッセイを用いた活性イオウ分子を分子内に有するタンパク質の同定
熊谷,嘉人; 吉田映子; 新開泰弘; 石井功; 赤池孝章
第14回日本NO学会学術集会 2014年5月
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286.
Activation of PTP1B/EGFR signal transduction pathway mediated by environmental electrophiles.
Kumagai,Yoshito
2014 Spring Annual Convention of Pharmaceutical Society of Korea 2014年4月 招待有り
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287.
Regulation of Covalent Modification of 2-Tert-Butyl-1,4-Benzoquinone to Keap1 through Glutathione-Mediated S-Transarylation.
Abiko,Y; Kumagai,Y
Society of Toxicology 53th Annual Meeting 2014年3月
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288.
Role of Reactive Sulfur Species in Reduction of Methylmercury Toxicity In Vitro and In Vivo.
Yoshida,E; Toyama,T; Kumagai,Y
Society of Toxicology 53th Annual Meeting 2014年3月
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289.
Ambient Vaper Samples Acrivate the Nrf2-ARE Pathway but Not an Inflammatory Response in Human Bronchial Epithelial BEAS-2B Cells.
Shinkai,Y; Nakajima,S; Eiguren-Fernandez,A; Stefano,ED; Schmitz,DA; Froines,JR; Cho,AK; Kumagai,Y
Society of Toxicology 53th Annual Meeting 2014年3月
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290.
Proteomics Analysis to Identify Sensor Proteins with Covalent Modification Associated with 1,4-Naphthoquinone-Induced Activation of Electrophilic Signal Transduction Pathways.
Hirose,R; Miura,T; Sha,R; Shinkai,Y; Tanaka-Kagawa,T; Kumagai,Y
Society of Toxicology 53th Annual Meeting 2014年3月
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291.
Activation of Nrf1/ARE pathway by cadmium in vascular endothelial cells.
Shinkai,Y; Kaji,T; Kumagai,Y
The Environmental Response Ⅳ 2014年2月
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292.
Identification of phytochemicals from Coriandrum sativum L. leaf extract to activate Nrf2 through electrophilic modification of the 2-alkenal group.
Abiko,Y; Mizokawa,M; Kumagai,Y
The Environmental Response Ⅳ 2014年2月
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293.
Cooperative role of the Keap1-Nrf2 pathway and CBS/CSE in methyl mercury toxicity.
Kumagai,Yoshito
The Environmental Response Ⅳ 2014年2月 招待有り
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294.
芳香族炭化水素キノン類による芳香族炭化水素受容体の活性化.
安孫子ユミ; Puga,Alvaro; 熊谷,嘉人
第13回分子予防環境医学研究会 2014年2月
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295.
S-Mercuration of protein disulfide isomerase results in cell death via endoplasmic reticulum stress
Kumagai,Yoshito
87th Annual Meeting of the Japanese-Pharmacological-Society 2014年
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296.
メチル水銀と活性イオウ分子.
熊谷,嘉人
環境省 メチル水銀研究ミーティング 2013年12月 招待有り
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297.
Coriandrum sativum L.葉抽出物に含有される脂肪族親電子物質による無機三価ヒ素の細胞毒性軽減.
安孫子ユミ; 溝川真衣; 熊谷,嘉人
第19回ヒ素シンポジウム 2013年11月
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298.
A unique redox signal transduction pathway regulated by reactive sulfur species.
Kumagai,Yoshito
The 2nd Human Biology Symposium 2013年10月 招待有り
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299.
Detoxification of methylmercury by hydrogen sulfide producing enzyme in vitro and in vivo.
Yoshida,E; Toyama,T; Kumagai,Y
The 8th Tsukuba Medical Science Research Meeting 2013年10月
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300.
Removal of 2-tert-butyl-1,4-benzoquinone from Keap1-TBQ adduct by glutathione-mediated S-transarylation.
Abiko,Y; Kumagai,Y
The 8th Tsukuba Medical Science Research Meeting 2013年10月
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