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沓村 憲樹

Kutsumura, Noriki

数理物質系（化学域）／国際統合睡眠医科学研究機構（WPI-IIIS） , 教授
Faculty of Pure and Applied Sciences／WPI-IIIS , Professor

http://nagase.wpi-iiis.tsukuba.ac.jp/

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  1. 1. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Kenta Maeda; Tomoya Sugai; Akihisa Tokuda; Keita Kajino (+2 著者) Noriki Kutsumura
      Bioorganic & medicinal chemistry letters 99: 129611 (2024) Semantic Scholar
  2. 2. 新規創製選択的オレキシン1受容体作動薬の鎮痛効果と疼痛モデルマウスにおける治療有効性の解析 橋本 佳応; 南雲 康行; 飯尾 啓太; 長谷川 大晟 (+7 著者) 長瀬 博
      日本神経精神薬理学会年会プログラム・抄録集 53回: 177 (2023)
  3. 3. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Kenta Maeda; Sayaka Ohrui; Akihisa Tokuda; Yasuyuki Nagumo (+4 著者) Hiroshi Nagase
      Organic letters 25: 3407 (2023) Semantic Scholar
  4. 4. Design and Synthesis of Orexin 1 Receptor-Selective Agonists Iio, Keita; Hashimoto, Kao; Nagumo, Yasuyuki; Amezawa, Mao (+13 著者) Saitoh, Tsuyoshi
      Journal of Medicinal Chemistry 66: 5453 (2023) Semantic Scholar
  5. 5. Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton Amezawa, Mao; Yamamoto, Naoshi; Nagumo, Yasuyuki; Kutsumura, Noriki (+3 著者) Saitoh, Tsuyoshi
      Bioorganic & Medicinal Chemistry Letters 82: 129151 (2023) Semantic Scholar
  6. 6. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo (+14 著者) Hiroshi Nagase
      European journal of medicinal chemistry 240: 114505 (2022)
  7. 7. Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors. Koki Katoh; Naoshi Yamamoto; Yukiko Ishikawa; Yoko Irukayama-Tomobe (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128527 (2022) Semantic Scholar
  8. 8. Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives. Koki Katoh; Noriki Kutsumura; Naoshi Yamamoto; Yasuyuki Nagumo (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128550 (2022) Semantic Scholar
  9. 9. Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton. Tsubasa Hino; Tsuyoshi Saitoh; Yasuyuki Nagumo; Naoshi Yamamoto (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128530 (2022)
  10. 10. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 60: 128555 (2022) Semantic Scholar
  11. 11. Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands. Keita Iio; Noriki Kutsumura; Yasuyuki Nagumo; Tsuyoshi Saitoh (+6 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 56: 128485 (2022) Semantic Scholar
  12. 12. Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives Tsubasa Hino; Noriki Kutsumura; Tsuyoshi Saitoh; Naoshi Yamamoto (+3 著者) Hiroshi Nagase
      TETRAHEDRON LETTERS 63: (2021) Semantic Scholar
  13. 13. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine. Yasuyuki Nagumo; Koki Katoh; Keita Iio; Tsuyoshi Saitoh (+8 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 30: 127360 (2020) Semantic Scholar
  14. 14. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities Noriki Kutsumura; Yasuaki Koyama; Tsuyoshi Saitoh; Naoshi Yamamoto (+7 著者) Hiroshi Nagase
      Molecules (2020) Semantic Scholar
  15. 15. Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. Tsuyoshi Saitoh; Kazunori Seki; Ryo Nakajima; Naoshi Yamamoto (+6 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 30: 126893 (2020) Semantic Scholar
  16. 16. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Saitoh T; Seki K; Nakajima R; Yamamoto N (+7 著者) Nagase H
      Bioorganic & medicinal chemistry letters 29: 2655 (2019) Semantic Scholar
  17. 17. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity Saitoh, Tsuyoshi; Seki, Kazunori; Nakajima, Ryo; Yamamoto, Naoshi (+7 著者) Nagase, Hiroshi
      Bioorganic & medicinal chemistry letters 29: 2655 (2019) Semantic Scholar
  18. 18. Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions Zhang Yan; Sugai Tomoya; Yamamoto Takashi; Yamamoto Naoshi (+4 著者) Nagase Hiroshi
      CHEMELECTROCHEM 6: 4194 (2019) Semantic Scholar
  19. 19. オレキシン 沓村 憲樹; 長瀬 博; 柳沢 正史
      Clinical Neuroscience Vol.37 (19年) 07月号 睡眠―正常生理とその異常 37: 787 (2019)
  20. 20. Total Synthesis of 3-epi-Juruenolide C Noriki Kutsumura; Mai Inagaki; Akito Kiriseko; Takao Saito
      Chemical and Pharmaceutical Bulletin 67: 594 (2019) Semantic Scholar
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  1. 1. アルカロイドの科学－生物活性を生みだす物質の探索から創薬の実際まで－ 長瀬博; 沓村憲樹 (担当:分担執筆, 範囲:第20章 オピオイドのドラッグデザインと医薬品開発)
    化学同人 2017年8月 (ISBN: 9784759814187)
  2. 2. 動物／疾患モデルの作成技術・病態解析・評価手法 長瀬博; 沓村憲樹 (担当:分担執筆, 範囲:難治性掻痒症治療薬ナルフラフィンの創出と痒みの最新メカニズム)
    技術情報協会 2017年8月 (ISBN: 9784861046650)
  3. 3. Cross Conjugation: Modern Dendralene, Radialene and Fulvene Chemistry Takao Saito; Noriki Kutsumura (担当:分担執筆, 範囲:The Diene-Transmissive Hetero-Diels–Alder Reaction)
    Wiley-VCH 2016年 (ISBN: 9783527334377)

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