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藤山知之

Fujiyama, Tomoyuki

国際統合睡眠医科学研究機構 , 助教
International Institute for Integrative Sleep Medicine , Assistant Professor

http://sleepymouse.jp/

オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。

1. Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice. Chi Lieu Kim Nguyen; Yumeno Kuba; Hoai Thu Le; Hossam Hassan Shawki (+19 著者) Seiya Mizuno
Cell death discovery 11: 17 (2025)
2. Partial activation of salt-inducible kinase 3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site Shinya Nakata; Tomoyuki Fujiyama; Fuyuki Asano; Haruna Komiya (+9 著者) Masashi Yanagisawa
SLEEP (2024) Semantic Scholar
3. Crucial role of TFAP2B in the nervous system for regulating NREM sleep. Ayaka Nakai; Mitsuaki Kashiwagi; Tomoyuki Fujiyama; Kanako Iwasaki (+4 著者) Yu Hayashi
Molecular brain 17: 13 (2024) Semantic Scholar
4. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice. Fuyuki Asano; Staci J Kim; Tomoyuki Fujiyama; Chika Miyoshi (+11 著者) Masashi Yanagisawa
Proceedings of the National Academy of Sciences of the United States of America 120: e2218209120 (2023) Semantic Scholar
5. Kinase signalling in excitatory neurons regulates sleep quantity and depth. Staci J Kim; Noriko Hotta-Hirashima; Fuyuki Asano; Tomohiro Kitazono (+23 著者) Hiromasa Funato
Nature 612: 512 (2022) Semantic Scholar
6. Mice Lacking Cerebellar Cortex and Related Structures Show a Decrease in Slow-Wave Activity With Normal Non-REM Sleep Amount and Sleep Homeostasis Tomoyuki Fujiyama; Henri Takenaka; Fuyuki Asano; Kazuya Miyanishi (+7 著者) Hiromasa Funato
Frontiers in Behavioral Neuroscience 16: 910461 (2022) Semantic Scholar
7. The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice. Jinhwan Choi; Staci J Kim; Tomoyuki Fujiyama; Chika Miyoshi (+3 著者) Hiromasa Funato
Frontiers in neuroscience 15: 739236 (2021) Semantic Scholar
8. Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice. Kazuya Murata; Asuka Mimura; Hayate Suzuki; Natsuki Mikami (+10 著者) Fumihiro Sugiyama
Journal of biochemistry (2021) Semantic Scholar
9. Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need. Kanako Iwasaki; Tomoyuki Fujiyama; Shinya Nakata; Minjeong Park (+10 著者) Masashi Yanagisawa
The Journal of neuroscience : the official journal of the Society for Neuroscience 41: 2733 (2021) Semantic Scholar
10. An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension. Gusty R T Ryanto; Koji Ikeda; Kazuya Miyagawa; Ly Tu (+5 著者) Noriaki Emoto
Nature communications 12: 1720 (2021) Semantic Scholar
11. Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β. Ayaka Nakai; Tomoyuki Fujiyama; Nanae Nagata; Mitsuaki Kashiwagi (+13 著者) Yu Hayashi
Genetics 216: 753 (2020) Semantic Scholar
12. Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. Minjeong Park; Chika Miyoshi; Tomoyuki Fujiyama; Miyo Kakizaki (+7 著者) Hiromasa Funato
Scientific reports 10: 8676 (2020) Semantic Scholar
13. Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway. Morito Sakikubo; Kenichiro Furuyama; Masashi Horiguchi; Shinichi Hosokawa (+9 著者) Yoshiya Kawaguchi
Scientific reports 8: 15812 (2018) Semantic Scholar
14. A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Honda T; Fujiyama T; Miyoshi C; Ikkyu A (+6 著者) Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America 115: 10458 (2018) Semantic Scholar
15. Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain Tomoyuki Fujiyama; Satoshi Miyashita; Yousuke Tsuneoka; Kazumasa Kanemaru (+14 著者) Mikio Hoshino
Cell Reports 24: 79 (2018) Semantic Scholar
16. Quantitative phosphoproteomic analysis of the molecular substrates of sleep need Zhiqiang Wang; Jing Ma; Chika Miyoshi; Yuxin Li (+20 著者) Qinghua Liu
Nature 558: 435 (2018) Semantic Scholar
17. Forward-genetics analysis of sleep in randomly mutagenized mice Hiromasa Funato; Chika Miyoshi; Tomoyuki Fujiyama; Takeshi Kanda (+33 著者) Masashi Yanagisawa
NATURE 539: 378 (2016) Semantic Scholar
18. Identification of mutations through dominant screening for obesity using C57BL/6 substrains Mohammad Sarowar Hossain; Fuyuki Asano; Tomoyuki Fujiyama; Chika Miyoshi (+16 著者) Masashi Yanagisawa
SCIENTIFIC REPORTS 6: 32453 (2016) Semantic Scholar
19. The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂. Ruffault PL; D'Autréaux F; Hayes JA; Nomaksteinsky M (+7 著者) Goridis C
eLife 2015: (2015)
20. Unipotent, Atoh1(+) progenitors maintain the Merkel cell population in embryonic and adult mice Margaret C. Wright; Erin G. Reed-Geaghan; Alexa M. Bolock; Tomoyuki Fujiyama (+1 著者) Stephen M. Maricich
JOURNAL OF CELL BIOLOGY 208: 367 (2015) Semantic Scholar

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1. 「眠気」の生化学的な実体に迫るー睡眠要求を規定するリン酸化タンパク質群の同定藤山知之, 柳沢正史 (担当:共著)
実験医学 2019年1月号 Vol.37 No.1 「なぜ、いま核酸医薬なのか」

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日本睡眠学会第４８回定期学術集会シンポジウム 34 「ムーンショット:睡眠基礎研究の最前線」 2024年7月招待有り
2. 終脳および橋延髄のNALCNはレム睡眠制御において異なる役割を持つ Tomoyuki Fujiyama; Hiromasa Funato; Masashi Yanagisawa
第73回日本薬理学会北部会次世代薬理学セミナー次世代神経薬理学の最前線 2022年9月招待有り
3. 脳の性別を決定する新たなメカニズム — Ptf1a遺伝子が脳の男性化・女性化に働く藤山知之
第29回日本行動内分泌研究会 2018年9月5日招待有り
4. Forebrain Ptf1a is required for sexual differentiation of the brain 藤山知之
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5. Forebrain Ptf1a is required for sexual differentiation of the brain 藤山知之
22nd Biennial Meeting of the International Society of Developmental Neuroscience 2018年5月22日
6. Hypothalamic Ptf1a is required for sexual differentiation of the brain and behavior 藤山知之
2017 SfN Annual Meeting 2017年11月11日
7. 連鎖解析と全エクソームシーケンスによるDreamless 変異家系特異的な一塩基置換の同定とCRISPR/Casによる再現藤山知之
第121回日本解剖学会総会・全国学術集会 2016年3月28日招待有り
8. 発生期視床下部に発現する遺伝子と脳の性分化藤山知之
名古屋大学高等研究院・若手新分野創成ワークショップ「脳を知り、疾患を理解する」招待有り