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新開 泰弘

ALUMNI 2025年11月現在、筑波大学が主たる所属機関ではありません

Yasuhiro, Shinkai

医学医療系 , 准教授
Faculty of Medicine , Associate Professor

http://www.md.tsukuba.ac.jp/chs/life_system/shinkai.htm

シグナル伝達の異常に起因した疾患 を治療する創薬開発に向けた研究
シグナル伝達と疾患リサーチユニット
Research for drug discovery to treat diseases caused by abnormal cellular signaling

2017-05-16

金保 安則 加藤 光保 熊谷 嘉人 高橋 智 渋谷 彰 渋谷 和子 入江 賢児 鈴木 裕之 船越 祐司 新開 泰弘
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome Akiyama, Masahiro; Shinkai, Yasuhiro; Yamakawa, Hiroto; Kim, Yun-GiKumagai, Yoshito
      Chemosphere 299: 134374 (2022) Semantic Scholar
  2. 2. Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan Horai, Sawako; Abiko, Yumi; Unoki, Takamitsu; Shinkai, Yasuhiro (+3 著者) Kumagai, Yoshito
      Chemosphere 295: 133833 (2022) Semantic Scholar
  3. 3. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage Liu, Jun; Kasai, Shuya; Tatara, Yota; Yamazaki, Hiromi (+13 著者) Itoh, Ken
      International Journal of Molecular Sciences 23: 3201 (2022) Semantic Scholar
  4. 4. Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain Unoki, Takamitsu; Akiyama, Masahiro; Shinkai, Yasuhiro; Kumagai, YoshitoFujimura, Masatake
      The Journal of toxicological sciences 47: 31 (2022) Semantic Scholar
  5. 5. Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells Takahashi, Musubu; Kubota, Ayaka; Fujie, Tomoya; Shinkai, Yasuhiro (+4 著者) Kaji, Toshiyuki
      BPB Reports 4: 175 (2021) Semantic Scholar
  6. 6. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways Takahashi, Musubu; Fujie, Tomoya; Nakano, Tsuyoshi; Hara, Takato (+5 著者) Kaji, Toshiyuki
      International journal of molecular sciences 22: 11762 (2021) Semantic Scholar
  7. 7. Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation Wang, Chen; Okita, Yukari; Zheng, Ling; Shinkai, Yasuhiro (+5 著者) Kato, Mitsuyasu
      Cancer science 112: 4187 (2021) Semantic Scholar
  8. 8. Chemical and Biological Characterization of Particulate Matter (PM 2.5) and Volatile Organic Compounds Collected at Different Sites in the Los Angeles Basin Cho, Arthur K; Shinkai, Yasuhiro; Schmitz, Debra A; Di Stefano, Emma (+5 著者) Melega, William P
      APPLIED SCIENCES-BASEL 10: (2020) Semantic Scholar
  9. 9. Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain Akiyama, Masahiro; Unoki, Takamitsu; Yoshida, Eiko; Ding, Yunjie (+3 著者) Kumagai, Yoshito
      Toxicology letters 330: 128 (2020) Semantic Scholar
  10. 10. Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone is rescued by α-crystallin chaperone Shinkai, Yasuhiro; Ding, Yunjie; Miura, Takashi; Kumagai, Yoshito
      The Journal of toxicological sciences 45: 37 (2020) Semantic Scholar
  11. 11. カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子を介した制御 新開, 泰弘; 秋山, 雅博; 熊谷, 嘉人
      硫酸と工業 73: 41 (2020)
  12. 12. 環境中親電子物質の毒性防御に働くシグナル伝達経路と活性イオウ分子による制御 新開, 泰弘; 熊谷, 嘉人
      Annual Meeting of the Japanese Society of Toxicology 47: W6 (2020)
  13. 13. 活性イオウ分子を介した親電子ストレス防御 鵜木, 隆光; 秋山, 雅博; 新開, 泰弘; 熊谷, 嘉人藤村, 成剛
      Annual Meeting of the Japanese Society of Toxicology 47: S30 (2020)
  14. 14. サルフェン硫黄によるレドックス制御と環境中親電子物質のフェーズゼロ反応 新開, 泰弘; 熊谷, 嘉人
      Annual Meeting of the Japanese Society of Toxicology 47: S30 (2020)
  15. 15. Identification, Characterization and Three-Dimensional Structure Modeling of Metallothionein-3 as a Sulfane Sulfur- and Zinc-MH2Binding Protein Shinkai, Yasuhiro; Ding, Yunjie; Akiyama, Masahiro; Unoki, Takamitsu (+3 著者) Kumagai, Yoshito
      FREE RADICAL BIOLOGY AND MEDICINE 145: S38 (2019) Semantic Scholar
  16. 16. Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload. Akiyuki Nishimura; Kakeru Shimoda; Tomohiro Tanaka; Takashi Toyama (+7 著者) Motohiro Nishida
      Science signaling 12: (2019) Semantic Scholar
  17. 17. Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both. Masahiro, Akiyama; T, Unoki; Yasuhiro, Shinkai; I, Ishii (+3 著者) Kumagai, Yoshito
      Environmental Health Perspectives 127: (2019) Semantic Scholar
  18. 18. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells Fujie, Tomoya; Takenaka, Fukuta; Yoshida, Eiko; Yasuike, Shuji (+4 著者) Kaji, Toshiyuki
      The Journal of Toxicological Sciences 44: 327 (2019) Semantic Scholar
  19. 19. The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications Lin, Joseph; Akiyama, Masahiro; Bica, Iris; Long, Faith T (+9 著者) Kumagai, Yoshito
      Chemical research in toxicology 32: 447 (2019) Semantic Scholar
  20. 20. The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications Lin, Joseph; Akiyama, Masahiro; Bica, Iris; Long, Faith T (+9 著者) Kumagai, Yoshito
      Chemical research in toxicology 32: 447 (2019) Semantic Scholar
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  1. 1. Intracellular Accumulation of Arsenic, Resulting in its Cytotoxicity and a Cellular Defense System Against Arsenic 新開, 泰弘
    2007年3月

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