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山下 年晴

Yamashita, Toshiharu

医学医療系 , 助教
Institute of Medicine , Assistant Professor

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  1. 1. Mesenchymal stem cell-derived extracellular vesicles reduce inflammatory responses to SARS-CoV-2 and Influenza viral proteins via miR-146a/NF-κB pathway Anggraeni, Neni; Vuong, Cat-Khanh; Silvia, Precella; Fukushige, Mizuho (+3 著者) Ohneda, Osamu
      SCIENTIFIC REPORTS 14: (2024) Semantic Scholar
  2. 2. Extracellular Vesicles Derived from Type 2 Diabetic Mesenchymal Stem Cells Induce Endothelial Mesenchymal Transition under High Glucose Conditions Through the TGFβ/Smad3 Signaling Pathway Vuong, Cat-Khanh; Fukushige, Mizuho; Ngo, Nhat-Hoang; Yamashita, Toshiharu (+5 著者) Ohneda, Osamu
      Stem cells and development 33: 262 - 275 (2024) Semantic Scholar
  3. 3. Extracellular Vesicles Derived from Type 2 Diabetic Mesenchymal Stem Cells Induce Endothelial Mesenchymal Transition under High Glucose Conditions Through the TGFβ/Smad3 Signaling Pathway Vuong, Cat-Khanh; Fukushige, Mizuho; Ngo, Nhat-Hoang; Yamashita, Toshiharu (+5 著者) Ohneda, Osamu
      Stem cells and development 33: 262 (2024) Semantic Scholar
  4. 4. Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression Nguyen; Hoai-Nga Thi; Vuong, Cat-Khanh; Fukushige, Mizuho (+8 著者) Ohneda, Osamu
      FRONTIERS IN ONCOLOGY 14: (2024) Semantic Scholar
  5. 5. Impairment of HIF-2α Expression Induced the Compensatory Overexpression of the HIF-1α/SDF-1 Axis to Promote Wound Healing Yamashita, Toshiharu; Vuong, Cat-Khanh; Ngo, Nhat-Hoang; Osaka, Motoo (+1 著者) Ohneda, Osamu
      STEM CELLS AND DEVELOPMENT 32: 592 (2023) Semantic Scholar
  6. 6. Transformed extracellular vesicles with high angiogenic ability as therapeutics of distal ischemic tissues Ngo, Nhat-Hoang; Chang, Yun-Hsuan; Khanh, Vuong Ca; Yamashita, Toshiharu (+4 著者) Ohneda, Osamu
      FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10: (2022) Semantic Scholar
  7. 7. Extracellular vesicles derived from Wharton's Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway Chang, Yun-Hsuan; Vuong, Cat-Khanh; Ngo, Nhat-Hoang; Yamashita, Toshiharu (+8 著者) Ohneda, Osamu
      Scientific reports 12: 13550 (2022) Semantic Scholar
  8. 8. Type 2 Diabetes Mellitus Promotes the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Cancer-Associated Fibroblasts, Induced by Breast Cancer Cells Chang, Yun-Hsuan; Ngo, Nhat-Hoang; Khanh, Vuong Ca; Yamashita, Toshiharu (+2 著者) Ohneda, Osamu
      STEM CELLS AND DEVELOPMENT 31: 659 (2022)
  9. 9. Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography Mukherjee, Pradipta; Fukuda, Shinichi; Lukmanto, Donny; Yamashita, Toshiharu (+9 著者) Yasuno, Yoshiaki
      BIOMEDICAL OPTICS EXPRESS 13: 4071 (2022) Semantic Scholar
  10. 10. SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells. Nguyen; Hoai-Nga Thi; Kawahara, Marie; Khanh, Vuong Ca (+2 著者) Ohneda, Osamu
      FRONTIERS IN ONCOLOGY 12: (2022) Semantic Scholar
  11. 11. Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy. P, Mukherjee; S, Fukuda; D, Lukmanto; T, Yamashita (+7 著者) Y., Yasuno
      Proc SPIE 11972 (2022)
  12. 12. Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation Yasuno, Yoshiaki; Abd El-Sadek; Ibrahim; Miyazawa, Arata (+11 著者) Matsusaka, Satoshi
      Proceedings Volume 11924, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV (2021)
  13. 13. Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography Okada, Kosuke; Mukherjee, Pradipta; Miyazawa, Arata; Fukuda, Shinichi (+8 著者) Yasuno, Yoshiaki
      Sci Rep. 11: 20054 (2021) Semantic Scholar
  14. 14. Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions Khanh, Vuong Ca; Fukushige, Mizuho; Chang, Yun-Hsuan; Hoang, Ngo Nha (+5 著者) Ohneda, Osamu
      Stem Cells and Development 30: 758 (2021) Semantic Scholar
  15. 15. Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography Mukherjee, P; Miyazawa, A; Shen, L. T. W; Fukuda, S (+8 著者) Yasuno, Y
      Proc. SPIE (2021) Semantic Scholar
  16. 16. Optical coherence tomography- based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids Abd El-Sadek; Ibrahim; Miyazawa, Arata; Shen, Larina Tzu-Wei (+8 著者) Yasuno, Yoshiaki
      BIOMEDICAL OPTICS EXPRESS 11: 6231 (2020) Semantic Scholar
  17. 17. Type 2 diabetes mellitus induced paracrine effects on breast cancer metastasis via extracellular vesicles derived from human mesenchymal stem cells Khanh, Vuong Ca; Fukushige, Mizuho; Moriguchi, Kana; Yamashita, Toshiharu (+2 著者) Ohneda, Osamu
      Stem Cells and Development 29: 1382 (2020) Semantic Scholar
  18. 18. Quantification of Ex Vivo Tissue Activity by Short and Long Time-Course Analysis of Multifunctional OCT Signals Ibrahim; Abd El-Sadek; Arata, Miyazawa; Larina, Shen (+8 著者) Yasuno, Yoshiaki
      Proc. SPIE 11228: 112282C (2020) Semantic Scholar
  19. 19. Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway Carolina, Erica; Kato, Toshiki; Vuong Cat, Khanh; Moriguchi, Kana (+3 著者) Ohneda, Osamu
      Frontiers in Medicine 5: (2018) Semantic Scholar
  20. 20. Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown Amin, Firman Zulkifli; Yamashita, Toshiharu; Ohneda, Osamu
      BMC research notes 11: 449 (2018) Semantic Scholar
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  1. 1. HIFのin vivoモデルによる機能解析 山下年晴; 大根田修 (担当:監修)
    実験医学 羊土社 2007年9月
  2. 2. 環境応答系転写因子の分子機構の解明 山下年晴; 山本, 雅之 (担当:監修)
    化学工業 2003年1月
  1. 1. Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway Yun-Hsuan, Chang; Vuong; Cat Khanh; Toshiharu, Yamashita; Osamu, Ohneda
    Tsukuba Global Science Week 2022 2022年9月30日
  2. 2. Nicotine and SARS-CoV-2 Protein Induce the Malignancy of Lung Cancer Cell. International Student Presentations of Medical and Life Sciences Session. Lomanto; Markus Yovian Widjaja; Nguyen; Hoai-Nga Thi; Khanh, Vuong Ca; Yamashita, Toshiharu; Ohneda, Osamu
    Tsukuba Global Science Week 2022 2022年9月29日
  3. 3. SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells Nguyen; Hoai-Nga Thi; Khanh, Vuong Ca; Yamashita, Toshiharu; Ohneda, Osamu
    Tsukuba Global Science Week 2022 2022年9月29日
  4. 4. Transformed Extracellular Vesicles with High Angiogenic Ability as Therapeutics of Distal Ischemic Tissues Ngo, Nhat-Hoang; Khanh, Vuong Ca; Yamashita, Toshiharu; Ohneda, Osamu
    Tsukuba Global Science Week 2022 2022年9月29日
  5. 5. Quantification of ex-vivo tissue activity by polarization dynamics imaging using Jones matrix optical coherence tomography Mukherjee, Pradipta; Miyazawa, Arata; Shen, Larina; Fukuda, Shinichi; Yamashita, Toshiharu; Oka, Yuki; Abd El-Sadek, Ibrahim; Makita, Shuichi; Matsusaka, Satoshi; Oshika, Tetsuro; Kano, Hideaki; Yasuno, Yoshiaki
    Biomedical Imaging and Sensing Conference 2020 2020年8月24日
  6. 6. Effect of soy protein intake on weak bones by the food restriction in young female rats Y, Aikawa; T, Narukawa; K, Kioka; T, Yamashita; N, Sasai; M, Ohtsuki; 麻見, 直美
    Human High Performance International Forum 2020 2020年2月17日 ARIHHPセンター
  7. 7. Quantification of ex vivo tissue activity by short and long timecourse analysis of multifunctional OCT signals El-Sadek; Ibrahim Abd; Miyazawa, Arata; Shen, Larina; Fukuda, Shinichi; Yamashita,Toshiharu; Oka, Yuki; Mukherjee, Pradipta; Makita, Shuichi; Matsusaka, Satoshi; Oshika, Tetsuro; Kano, Hideaki; Yasuno, Yoshiaki
    SPIE Photonics West/ BiOS 2020 2020年2月1日
  8. 8. Impairment of Sirt1 plays the key role in the dysfunction of mesenchymal stem cells in beige adipogenesis Vuong Cat, Khanh; Yamashita, Toshiharu; Ohneda, Osamu
    The Joint Young Research Meeting in Biomedical Science 2020年1月10日
  9. 9. Study the effects of type 2 diabetes mellitus on functions of Wharton jelly's Mesenchymal stem cells for the treatment of diabetic foot ulcer Sipayung; Shinta Masyta; Khanh, Vuong Ca; Yamashita, Toshiharu; Ohneda, Osamu
    The Joint Young Research Meeting in Biomedical Science 2020年1月10日
  10. 10. Birefringence dynamics imaging for ex-vivo tissue activity quantification using polarization-sensitive optical coherence tomography Mukherjee, Pradipta; El-Sadek; Ibrahim Abd; Miyazawa, Arata; Makita, Shuichi; Shen, Larina; Fukuda, Shinichi; Yamashita, Toshiharu; Oka, Yuki; Matsusaka, Satoshi; Oshika, Tetsuro; Kano, Hideaki; Yasuno, Yoshiaki
    Optics Photonics Japan 2019 （日本光学会年次講演会） 2019年12月2日
  11. 11. Short and long time-course ex vivo tissues activity quantification by multifunctional OCT El-Sadek; Ibrahim Abd; Miyazawa, Arata; Shen, Larina; Fukuda, Shinichi; Yamashita,Toshiharu; Oka, Yuki; Mukherjee, Pradipta; Makita, Shuichi; Matsusaka, Satoshi; Oshika, Tetsuro; Kano, Hideaki; Yasuno, Yoshiaki
    Optics Photonics Japan 2019 （日本光学会年次講演会） 2019年12月2日
  12. 12. 老化による脂肪組織由来間葉系幹細胞の創傷治癒能に対する影響の解析 原彩美; Vuong, Cat Khanh; Toshiharu, Yamashita; Osamu, Ohneda
    第18回日本再生医療学会総会 2019年3月21日
  13. 13. より高い治療効果を持つ機能性血管内皮前駆細胞 (EPC) の作成 佐藤悠樹; Vuong, Cat Khanh; Toshiharu, Yamashita; Osamu, Ohneda
    第18回日本再生医療学会総会 2019年3月21日
  14. 14. Effects of aging on mesenchymal stem cells VUONG CAT; KHANH; Yamashita, Toshiharu; Ohneda, Osamu
    The 1st University of Tsukuba-University of Science Vietnam Joint Symposium 2019 2019年2月23日
  15. 15. Study the effects of Type 2 diabetes mellitus on beige adipogenesis of Mesenchymal stem cells Takeuchi, Kosuke; Khanh, Vuong Ca; Yamashita, Toshiharu; Ohneda, Osamu
    Tsukuba Science Week 2018 2018年9月20日
  16. 16. The ectopic FOXA1 expression correlates to the luminal breast cancer stem cells Tachi,K; Shiraishi,A; Bando,Hiroko; Yamashita,T; Tsuboi,I; Kato,T; Ichioka,E; Tsushima,Y; Ikeda,T; Iguchi,A; Hara,H; Ohneda,O
    39Th San Antonio Breast Cancer Symposium 2016年12月6日
  17. 17. The ectopic FOXA1 expression correlates to the luminal breast cancer stem cells Tachi, K; Shiraishi, A; Bando, H; Yamashita, T; Tsuboi, I; Kato, T; Ichioka, E; Tsushima, Y; Ikeda, T; Iguchi, A; Hara, H; Ohneda, O
    San Antonio Breast Cancer Symposium 2016年12月6日
  18. 18. 筑波大学における臨地実習前OSCEの開発に向けた取組 會田, 雄一; 山内, 一由; 上妻, 行則; 渋谷, 和子; 上杉, 憲子; 中川, 嘉; 吉田, 文代; 山下, 年晴; 小池, 朗; 二宮, 治彦
    第11回日本臨床検査学教育学会学術大会 2016年8月31日
  19. 19. Dual Functions of Hypoxia Inducible Factor-1 alpha for the Commitment of Mouse Embryonic Stem Cells Toward a Neural Lineage Takasaki,Mami; Zhao,Yang; Tsuboi,Ikki; Yamashita,Toshiharu; Ohneda,Osamu
    第47回日本発生生物学会 2014年5月28日
  20. 20. Deficient expression of HIF-2a in spleen results in compensatory angiogenesis by up-regulated of HIF-1a IkkiTsuboi; 山下,年晴; Satomi,Kobayashi; Osamu,Ohneda
    第36回 日本分子生物学会 2013年12月3日
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