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臼井 健郎

Usui, Takeo

生命環境系 , 教授
Institute of Life and Environmental Sciences , Professor

https://sites.google.com/view/usui-lab

化合物の標的は何？～規薬剤開発の架け橋として～

2017-12-12

臼井 健郎
新しいタイプの抗がん剤開発につながる成果 ～γ－チューブリン特異的阻害剤の開発に成功～

2016-09-27

臼井 健郎 木越 英夫
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of laeA gene introduction Aoi Kimishima; Sota Honma; Atsushi Kimishima; Atsuka Nishitomi (+11 著者) Yukihiro Asami
      Journal of Pesticide Science 49: 224 (2024)
  2. 2. The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene Honma, Sota; Kimishima, Aoi; Kato, Satoshi; Horiuchi, Akari (+11 著者) Asami, Yukihiro
      Bioorganic Medicinal Chemistry Letters 113: (2024) Semantic Scholar
  3. 3. Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates. Aoi Kimishima; Atsuka Nishitomi; Iori Tsuruoka; Masako Honsho (+9 著者) Yukihiro Asami
      Journal of pesticide science 49: 159 (2024) Semantic Scholar
  4. 4. Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity Kimishima, Aoi; Nishitomi, Atsuka; Tsuruoka, Iori; Sakai, Katsuyuki (+18 著者) Asami, Yukihiro
      Bioscience, biotechnology, and biochemistry 88: 1212 (2024) Semantic Scholar
  5. 5. Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers Kimishima, Aoi; Nishitomi, Atsuka; Kondo, Naozumi; Honma, Sota (+9 著者) Asami, Yukihiro
      Bioscience, biotechnology, and biochemistry 88: 1242 (2024) Semantic Scholar
  6. 6. Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene Sota Honma; Aoi Kimishima; Atsushi Kimishima; Masako Honsho (+11 著者) Yukihiro Asami
      Bioscience, Biotechnology, and Biochemistry (2024) Semantic Scholar
  7. 7. Design, synthesis, and biological evaluation of new biaryl derivatives of cycloalkyl diacetamide bearing chalcone moiety as type II c-MET kinase inhibitors Salarinejad, Somayeh; Seyfi, Soheila; Hayashi, Seiko; Moghimi, Setareh (+4 著者) Foroumadi, Alireza
      MOLECULAR DIVERSITY Epub: (2024)
  8. 8. Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi Kimishima, Aoi; Hagimoto, Daichi; Honsho, Masako; Sakai, Katsuyuki (+7 著者) Asami, Yukihiro
      ORGANIC LETTERS 26: 597 (2024) Semantic Scholar
  9. 9. Capsaicin indirectly regulates TRPA1 via the arachidonic acid cascade, resulting in TJ opening Kanda, Yusuke; Mukaiyama, Minagi; Yamasaki, Yohei; Usui, TakeoNagumo, Yoko
      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 88: 44 (2023) Semantic Scholar
  10. 10. RSK4 confers paclitaxel resistance to ovarian cancer cells, which is resensitized by its inhibitor BI-D1870 Nagumo, Yoko; Villareal, Myra O; Isoda, Hiroko; Usui, Takeo
      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 679: 23 (2023) Semantic Scholar
  11. 11. X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener. Minagi Mukaiyama; Chihiro Uchiyama; Akane Fukuda; Yoshiki Nakazawa (+13 著者) Takeo Usui
      Journal of medicinal chemistry 66: 8717 (2023) Semantic Scholar
  12. 12. Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics Kudo, Fumitaka; Kishikawa, Kosuke; Tsuboi, Kazuma; Kido, Takafusa (+4 著者) Eguchi, Tadashi
      Chembiochem : a European journal of chemical biology 24: e202200670 (2023) Semantic Scholar
  13. 13. A Combination Strategy of Multidrug-Sensitive Budding Yeast and Chemical Modifications Enabling to Find a New Overlooked Antifungal Compound, Sakurafusariene, from In-House Fractionated Library Aoi Kimishima; Yuki Ono; Katsuyuki Sakai; Kazunari Sakai (+10 著者) Yukihiro Asami
      Journal of Agricultural and Food Chemistry (2023) Semantic Scholar
  14. 14. Development of Gatastatin G2, alpha gamma-Tubulin-specific Inhibitor Hayakawa, Ichiro; Usui, Takeo
      JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 80: 563 (2022) Semantic Scholar
  15. 15. High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds 大貫, 慎輔; 小川, 樹; 一刀, かおり; Fachuang, Lu (+14 著者) 大矢, 禎一
      NPJ Systems Biology and Applications 8: 3 (2022) Semantic Scholar
  16. 16. 注射・点滴不要のバイオ医薬品投与法の開発 向山, 海凪; 南雲, 陽子; 臼井, 健郎
      化学工業 72: 796 (2021)
  17. 17. Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria. Katsuyuki Sakai; Yufu Unten; Aoi Kimishima; Kenichi Nonaka (+8 著者) Satoshi Ōmura
      Journal of industrial microbiology & biotechnology (2021) Semantic Scholar
  18. 18. Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis Uchiyama, Chihiro; Fukuda, Akane; Mukaiyama, Minagi; Nakazawa, Yoshiki (+12 著者) Hayashi, Yoshio
      Angewandte Chemie (International ed. in English) 60: 8792 (2021) Semantic Scholar
  19. 19. Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid-Selective Adenylation Enzyme HitB Kudo, Fumitaka; Takahashi, Sotaro; Miyanaga, Akimasa; Nakazawa, Yuichiro (+8 著者) Eguchi, Tadashi
      ACS chemical biology 16: 539 (2021) Semantic Scholar
  20. 20. Dual Inhibition of gamma-Tubulin and Plk1 Induces Mitotic Cell Death Ebisu, Haruna; Shintani, Kana; Chinen, Takumi; Nagumo, Yoko (+5 著者) Usui, Takeo
      FRONTIERS IN PHARMACOLOGY 11: (2021) Semantic Scholar
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  1. 1. γ−チューブリン特異的阻害剤 ガタスタチンG2の開発 早川, 一郎; 臼井, 健郎
    公益社団法人 有機合成化学協会 2022年6月
  2. 2. 有機合成化学協会誌 臼井, 健郎
    2022年6月
  3. 3. The Yeast Role in Medical Applications Chinen, Takumi; Hamada, Keisuke; Taguchi, Akihiro; Asami, Yukihiro; Shiomi, Kazuro; Hayashi, Yoshio; Usui, Takeo (担当:分担執筆, 範囲:Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics)
    2018年1月 (ISBN: 9789535137351)
  4. 4. Bioprobes (second edition) Hiroyuki, Koshino; Usui, Takeo (担当:分担執筆, 範囲:Bioprobes at a Glance)
    Springer Japan KK 2017年4月 (ISBN: 9784431565277)
  5. 5. Protein Targeting with Small Molecules Chemical Biology Techniques and Application Osada; H. edited Leonid; L. Chepelev; Michel, Dumontier; Yasuaki, Kabe; Mamoru, Hatakeyama; Satoshi, Sakamoto; Kosuke, Nishio; Hiroshi, Handa; Naoki, Kanoh; Yoon, Sun Cho; Ho, Jeong Kwon; Adrian, P. Neal; Carsten, Schultz; Nikolai, L. Chepelev; Hooman, Shadnia; William, G. Willmore; James, S. Wrigh; Yuichi, Hashimoto; Tatsuro, Kawamura; Mitsuhiro, Kitagawa; Masaya, Imoto; Prabhani; U. Atukorale; Sean, S. Choi; Udayanath, Aich; Christopher; T. Campbell; M; Adam Meledeo; Kevin, J. Yarem; Shinichi, Nishimura; Yoko, Yashiroda; Minoru, Yoshida; Takeo, Usui; Akiko, Saito; Hiroyuki, Osada
    Wiley 2009年1月
  6. 6. 天然由来のバイオプローブを用いたケミカルジェネティクスとケミカルゲノミクス 叶直樹; 清水史郎; 臼井健郎; 長田裕之 (担当:監修)
    蛋白質核酸酵素 2005年1月
  7. 7. バイオプローブの探索と細胞内標的分子の同定 臼井健郎; 叶直樹; 清水史郎; 長田裕之 (担当:監修)
    実験医学 2005年1月
  8. 8. 微小管に作用するアルカロイド化合物～新しい微小管作用薬開発のリード化合物として 臼井健郎; 長田裕之 (担当:監修)
    化学と生物 2001年1月
  9. 9. Bioprobe 長田裕之; 吉田稔; 井本正哉; 永井和夫; 片岡孝夫; 臼井健郎
    Springer 2000年1月
  10. 10. アポトーシス誘導性バイオプローブの探索と作用機構 長田裕之; 臼井健郎; 掛谷秀昭 (担当:監修)
    バイオインダストリー 1998年1月
  11. 11. プロテインキナーゼ阻害剤による細胞周期の脱制御に関する研究 臼井, 健郎
    1995年3月
  12. 12. 特異的阻害剤による細胞周期の脱制御と細胞の倍数化 吉田稔; 臼井健郎 (担当:監修)
    Cell Science 1992年1月

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