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下村 治

Shimomura, Osamu

医学医療系 , 講師
Institute of Medicine , Assistant Professor

膵がんの免疫回避能力を糖鎖でコントロール　糖鎖免疫チェックポイント分子の新規探索技術を開発

2026-01-13

小田 竜也 下村 治 久野 朗広
膵がん細胞表面の糖鎖をレクチン融合薬で狙い撃ち ～ ポスト抗体医薬としての新規抗がん治療法開発へ ～

2017-12-19

下村 治 小田 竜也 大河内 信弘
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. 原発性肝癌に対するalbumin-bilirubin score と 肝切除率での肝切除後重症肝不全予測 高橋, 一広; 蒲原, 知斗; 五所, 正彦; 中橋, 宏充 (+6 著者) 小田, 竜也
      日本門脈圧亢進症学会雑誌 32: 138 (2025)
  2. 2. Promoting Pancreatic Fistula Healing After Pancreaticoduodenectomy Through Internal Drainage of Pancreatic Juice Into the Jejunum Miyazaki, Yoshihiro; Hashimoto, Shinji; Shimomura, Osamu; Nakahashi, Hiromitsu (+9 著者) Oda, Tatsuya
      World journal of surgery (2025)
  3. 3. QUANTITATIVE ANALYSIS OF THE IMPACT OF C421A MUTATION ON BCRP ACTIVITY IN HUMAN ILEAL CRYPT-DERIVED DIFFERENTIATED CELLS Namai, Mana; Hashimoto, Yoshiki; Michiba, Kazuyoshi; Shimomura, Osamu (+6 著者) Kusuhara, Hiroyuki
      DRUG METABOLISM AND PHARMACOKINETICS 61: (2025)
  4. 4. Identification of CLEC10A as a human lectin for pancreatic ductal adenocarcinoma Tsukamoto, Shuntaro; Tateno, Hiroaki; Shimomura, Osamu; Yamamoto, Kana (+5 著者) Oda, Tatsuya
      Scientific reports 15: (2025)
  5. 5. Characterization of intestinal transporters in human ileal spheroid-derived differentiated cells for the prediction of intestinal drug absorption Michiba, Kazuyoshi; Namai, Mana; Hashimoto, Yoshiki; Shimomura, Osamu (+6 著者) Kusuhara, Hiroyuki
      DRUG METABOLISM AND DISPOSITION 53: (2025)
  6. 6. 血液型不適合腎移植後のT 細胞糖鎖変化に対する網羅的解析-B cell tolerance に注目して 高橋, 一広; 古屋 欽司; 下村, 治; 舘野, 浩章小田, 竜也
      BIO Clinica 40: 93 (2025)
  7. 7. Hypoxia at 3D organoid establishment selects essential subclone within heterogenous pancreatic cancer Kumano, Koichiro; Nakahashi, Hiromitsu; Osumi, Satoko; Komatsuzaki, Shuhei (+7 著者) Oda, Tatsuya
      CANCER SCIENCE 116: 879 (2025)
  8. 8. Development of the serotonin release assay with enterochromaffin cell-rich human intestinal organoids for the risk evaluation of drug-induced emesis Hashimoto, Yoshiki; Maeda, Kazuya; Shimomura, Osamu; Miyazaki, Yoshihiro (+2 著者) Kusuhara, Hiroyuki
      TOXICOLOGICAL SCIENCES Epub: (2024)
  9. 9. 手術手技 膵腸吻合部に意図的内ドレナージ孔を作製する新規膵腸吻合法(IIDH法) 橋本, 真治; 下村, 治; 宮﨑, 貴寛; 土井, 愛美 (+1 著者) 小田, 竜也
      手術 78: 955 (2024)
  10. 10. Idiopathic superior mesenteric venous thrombosis requiring bowel resection: a report of four cases Kamohara, Kazuto; Miyazaki, Yoshihiro; Nakahashi, Hiromitsu; Furuya, Kinji (+9 著者) Oda, Tatsuya
      SURGICAL CASE REPORTS 10: 122 (2024) Semantic Scholar
  11. 11. DEVELOPMENT OF SEROTONIN RELEASE ASSAY WITH CULTURED ENTEROCHROMAFFIN CELLS FOR THE RISK ASSESSMENT OF EMESIS INDUCED BY TYROSINE KINASE INHIBITORS Hashimoto, Yoshiki; Kazuya, Maeda; Shimomura, Osamu; Miyazaki, Yoshihiro (+2 著者) Kusuhara, Hiroyuki
      DRUG METABOLISM AND PHARMACOKINETICS 55: (2024)
  12. 12. Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy Takahashi, Kazuhiro; Gosho, Masahiko; Miyazaki, Yoshihiro; Nakahashi, Hiromitsu (+9 著者) Oda, Tatsuya
      WORLD JOURNAL OF GASTROENTEROLOGY 30: 2006 (2024) Semantic Scholar
  13. 13. Clinical Benefits of Reducing Dead Space Using a Closed Suction Drain and Subcutaneous Large-bite Buried Suture Technique to Prevent Superficial Surgical-site Infections Following Primary Closure of a Diverting Stoma Ohara, Yusuke; Owada, Yohei; Kim, Jaejeong; Moue, Shoko (+7 著者) Oda, Tatsuya
      Journal of the anus, rectum and colon 8: 70 (2024) Semantic Scholar
  14. 14. Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations Nakahashi, Hiromitsu; Oda, Tatsuya; Shimomura, Osamu; Akashi, Yoshimasa (+6 著者) Tateno, Hiroaki
      Journal of oncology 2024: (2024) Semantic Scholar
  15. 15. Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer Kumano, Koichiro; Nakahashi, Hiromitsu; Louphrasitthiphol, Pakavarin; Kuroda, Yukihito (+8 著者) Oda, Tatsuya
      FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 12: (2024) Semantic Scholar
  16. 16. Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys Hashimoto, Yoshiki; Maeda, Kazuya; Shimomura, Osamu; Miyazaki, Yoshihiro (+3 著者) Kusuhara, Hiroyuki
      Toxicology in vitro : an international journal published in association with BIBRA 93: 105691 (2023) Semantic Scholar
  17. 17. Triple modal treatment comprising with proton beam radiation, hyperthermia, and gemcitabine/nab-paclitaxel for locally advanced pancreatic cancer: a phase I/II study protocol (TT-LAP trial) Shimomura, Osamu; Endo, Masato; Makishima, Hirokazu; Yamada, Takeshi (+21 著者) Oda, Tatsuya
      BMC cancer 23: 624 (2023) Semantic Scholar
  18. 18. Total Superior Mesenteric Artery Nerve Plexus Preservation During Pancreaticoduodenectomy for Pancreatic Cancer Miyazaki, Yoshihiro; Oda, Tatsuya; Shimomura, Osamu; Hashimoto, Shinji (+7 著者) Enomoto, Tsuyoshi
      World journal of surgery (2023) Semantic Scholar
  19. 19. Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18 F-labeled rBC2LCN lectin Kuroda, Yukihito; Oda, Tatsuya; Shimomura, Osamu; Louphrasitthiphol, Pakavarin (+2 著者) Hatano, Kentaro
      Cancer science (2023) Semantic Scholar
  20. 20. Culture of circulating tumor cells using a microfilter device Furukawa, Atsuko; Mori, Tomoko; Shimomura, Osamu; Araki, Kazuhisa (+1 著者) Matsusaka, Satoshi
      ONCOLOGY REPORTS 49: (2023) Semantic Scholar
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  1. 1. BIO Clinica 高橋, 一広; 古屋 欽司; 下村, 治; 舘野, 浩章; 小田, 竜也
    2025年2月
  2. 2. 移植 高橋, 一広; 古屋, 欽司; 臼井, 丈一; 木村, 友和; 宮崎, 貴寛; 下村, 治; 西山, 博之; 小田, 竜也; 湯沢, 賢治; 山縣, 邦弘
    2023年8月
  3. 3. 医学のあゆみ 小田, 竜也; 下村 治; 館野浩章 (担当:分担執筆, 範囲:レクチンによる糖鎖標的膵癌治療の開発)
    医歯薬出版株式会社 2020年4月
  4. 4. GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG) Kajihara, Yasuhiro; Yamamoto, Kenji; Satoh, Mitsuo; Manabe, Shino; Oda, Tatsuya; Shimomura, Osamu; Tateno, Hiroaki; Hirabayashi, Jun; Sakurai, Kazuo; Miyagawa, Shuji; Tanaka, Katsunori; Fukuda, Michiko N; Nonaka, Motohiro (担当:分担執筆, 範囲:Glycoengineering)
    SPRINGER-VERLAG SINGAPORE PTE LTD 2019年 (ISBN: 9789811358562)
  5. 5. 消化器・肝臓内科 高橋一広; 荒木一寿; 竹内朋代; 倉田昌直; 小川光一; 下村, 治; 榎本剛史; 小田, 竜也; 大河内信弘 (担当:分担執筆, 範囲:多発肝嚢胞性疾患の診断・分類・治療 －当科での外科的治療経験と併せて－)
    科学評論社 2018年

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