ホーム > 斉藤 毅/ Saito, Tsuyoshi

斉藤 毅

Saito, Tsuyoshi

医学医療系 , 准教授
Institute of Medicine , Associate Professor

https://wpi-iiis.tsukuba.ac.jp/japanese/research/member/detail/tsuyoshisaitoh/

光により脳内のアデノシン活性を増強し睡眠を誘導する薬物の開発に成功

2024-05-21

LAZARUS MICHAEL 斉藤 毅
TRiSTAR第3期フェロー（2023年）斉藤 毅

2023-09-01

斉藤 毅
自然に近い眠りを誘う新たな不眠症治療薬の可能性 〜睡眠誘発物質アデノシンのシグナル伝達経路への新アプローチ〜

2019-04-02

斉藤 毅 LAZARUS MICHAEL
麻薬性鎮痛薬による眠気に対する新しい戦略を提示 ～眠気の治療薬としてのオレキシン受容体作動薬の可能性～

2018-12-11

柳沢 正史 斉藤 毅
ナルコレプシーの病因治療効果を確認 ～目覚めを制御する低分子医薬の新たな効果～

2017-08-22

斉藤 毅 VOGT Kaspar Mnuel 柳沢 正史
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity. Kaito Arai; Yuki Ono; Natsumi Hirai; Yuki Sugiura (+7 著者) Asuka Inoue
      Biochimica et biophysica acta. Molecular basis of disease 167566 (2024)
  2. 2. Tailoring Unstrained Pyrrolidines via Reductive C–N Bond Cleavage with Lewis Acid and Photoredox Catalysis Marina, Hirano; Kazuhiro, Aida; Tsuyoshi, Saitoh; Takashi, Yamamoto (+2 著者) Junichiro, Yamaguchi
      ChemRxiv (2024)
  3. 3. Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors Koustav Roy; Xuzhao Zhou; Rintaro Otani; Ping-Chuan Yuan (+17 著者) Michael Lazarus
      Nature Communications 15: (2024) Semantic Scholar
  4. 4. Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor Chiyo Suno-Ikeda; Ryo Nishikawa; Riko Suzuki; Seiya Iwata (+14 著者) Ryoji Suno
      bioRxiv (2024) Semantic Scholar
  5. 5. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Kenta Maeda; Tomoya Sugai; Akihisa Tokuda; Keita Kajino (+2 著者) Noriki Kutsumura
      Bioorganic & medicinal chemistry letters 99: 129611 (2024) Semantic Scholar
  6. 6. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology Keita Kajino; Akihisa Tokuda; Tsuyoshi Saitoh
      The Journal of Biochemistry (2024)
  7. 7. The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala. Ayako Kawaminami; Daisuke Yamada; Toshinori Yoshioka; Azumi Hatakeyama (+4 著者) Akiyoshi Saitoh
      Neuropsychopharmacology reports (2023) Semantic Scholar
  8. 8. Selective electro-oxidation of cumene utilizing a flow reactor equipped with diamond electrodes Nihongi, Shogo; Matsuoka, Riyako; Saito, Tsuyoshi; Einaga, YasuakiYamamoto, Takashi
      Current Research in Green and Sustainable Chemistry 7: 100378 (2023) Semantic Scholar
  9. 9. Face validation and pharmacologic analysis of Sik3Sleepy mutant mouse as a possible model of idiopathic hypersomnia Elhosainy, Asmaa; Suzuki-Abe, Haruka; Kaushik; Mahesh K (+6 著者) Yanagisawa, Masashi
      European journal of pharmacology 954: (2023) Semantic Scholar
  10. 10. Chemogenetic activation of G12 signaling enhances adipose tissue browning. Yuki Ono; Ryo Ito; Kaito Arai; Gurdeep Singh (+5 著者) Asuka Inoue
      Signal transduction and targeted therapy 8: 307 (2023) Semantic Scholar
  11. 11. The present and future of synthetic orexin receptor agonists Saitoh, Tsuyoshi; Sakurai, Takeshi
      Peptides 167: (2023) Semantic Scholar
  12. 12. Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia Asmaa Elhosainy; Haruka Suzuki-Abe; Mahesh K. Kaushik; Staci J. Kim (+5 著者) Masashi Yanagisawa
      European Journal of Pharmacology 175877 - 175877 (2023) Semantic Scholar
  13. 13. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Kenta Maeda; Sayaka Ohrui; Akihisa Tokuda; Yasuyuki Nagumo (+4 著者) Hiroshi Nagase
      Organic letters 25: 3407 (2023) Semantic Scholar
  14. 14. Design and Synthesis of Orexin 1 Receptor-Selective Agonists Iio, Keita; Hashimoto, Kao; Nagumo, Yasuyuki; Amezawa, Mao (+13 著者) Saitoh, Tsuyoshi
      Journal of Medicinal Chemistry 66: 5453 (2023) Semantic Scholar
  15. 15. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice Lin, Yang; Roy, Koustav; Ioka, Shuji; Otani, Rintaro (+9 著者) Lazarus, Michael
      Frontiers in pharmacology 14: (2023) Semantic Scholar
  16. 16. Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton Amezawa, Mao; Yamamoto, Naoshi; Nagumo, Yasuyuki; Kutsumura, Noriki (+3 著者) Saitoh, Tsuyoshi
      Bioorganic & Medicinal Chemistry Letters 82: 129151 (2023) Semantic Scholar
  17. 17. オピオイドδ受容体作動薬KNT-127による恐怖記憶の再固定化阻害作用およびその作用部位探索 河南 絢子; 山田 大輔; 吉岡 寿倫; 畠山 梓摘 (+3 著者) 斎藤 顕宜
      Proceedings for Annual Meeting of The Japanese Pharmacological Society 97: 3-B-P-089 (2023)
  18. 18. Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes Mana Kitano; Tsuyoshi Saitoh; Shigeru Nishiyama; Yasuaki EinagaTakashi Yamamoto
      Beilstein Journal of Organic Chemistry 18: 1154 (2022) Semantic Scholar
  19. 19. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo (+14 著者) Hiroshi Nagase
      European Journal of Medicinal Chemistry 240: 114505 (2022)
  20. 20. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
      Bioorganic & Medicinal Chemistry Letters 60: 128555 (2022) Semantic Scholar
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  1. 1. 日本応用酵素協会誌 斉藤, 毅
    公益財団法人 日本応用酵素協会 2024年3月
  2. 2. Diamond Electrodes Fundamentals and Applications Takashi Yamamoto; Tsuyoshi Saitoh (担当:共著, 範囲:Electro-OrganicSynthesis, 177–195)
    Springer Nature Singapore Pte Ltd. 2022年 (ISBN: 9789811678332)
  3. 3. 有機電解合成の新潮流 斉藤毅; 西山繁 (担当:共著, 範囲:第12 章 生理活性天然物の電解合成)
    シーエムシー出版 2021年11月 (ISBN: 9784781316260)
  4. 4. 天然物の化学 II 斉藤, 毅; 長瀬, 博 (担当:分担執筆, 範囲:睡眠覚醒を制御する化学物質)
    東京化学同人 2018年7月 (ISBN: 9784807915057)

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