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斉藤毅

Saito, Tsuyoshi

医学医療系 , 准教授
Institute of Medicine , Associate Professor

https://wpi-iiis.tsukuba.ac.jp/japanese/research/member/detail/tsuyoshisaitoh/

オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。

1. Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity. Kaito Arai; Yuki Ono; Natsumi Hirai; Yuki Sugiura (+7 著者) Asuka Inoue
Biochimica et biophysica acta. Molecular basis of disease 167566 (2024)
2. Tailoring Unstrained Pyrrolidines via Reductive C–N Bond Cleavage with Lewis Acid and Photoredox Catalysis Marina, Hirano; Kazuhiro, Aida; Tsuyoshi, Saitoh; Takashi, Yamamoto (+2 著者) Junichiro, Yamaguchi
ChemRxiv (2024)
3. Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors Koustav Roy; Xuzhao Zhou; Rintaro Otani; Ping-Chuan Yuan (+17 著者) Michael Lazarus
Nature Communications 15: (2024) Semantic Scholar
4. Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor Chiyo Suno-Ikeda; Ryo Nishikawa; Riko Suzuki; Seiya Iwata (+14 著者) Ryoji Suno
bioRxiv (2024) Semantic Scholar
5. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Kenta Maeda; Tomoya Sugai; Akihisa Tokuda; Keita Kajino (+2 著者) Noriki Kutsumura
Bioorganic & medicinal chemistry letters 99: 129611 (2024) Semantic Scholar
6. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology Keita Kajino; Akihisa Tokuda; Tsuyoshi Saitoh
The Journal of Biochemistry (2024)
7. The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala. Ayako Kawaminami; Daisuke Yamada; Toshinori Yoshioka; Azumi Hatakeyama (+4 著者) Akiyoshi Saitoh
Neuropsychopharmacology reports (2023) Semantic Scholar
8. Selective electro-oxidation of cumene utilizing a flow reactor equipped with diamond electrodes Nihongi, Shogo; Matsuoka, Riyako; Saito, Tsuyoshi; Einaga, YasuakiYamamoto, Takashi
Current Research in Green and Sustainable Chemistry 7: 100378 (2023) Semantic Scholar
9. Face validation and pharmacologic analysis of Sik3^Sleepy mutant mouse as a possible model of idiopathic hypersomnia Elhosainy, Asmaa; Suzuki-Abe, Haruka; Kaushik; Mahesh K (+6 著者) Yanagisawa, Masashi
European journal of pharmacology 954: (2023) Semantic Scholar
10. Chemogenetic activation of G12 signaling enhances adipose tissue browning. Yuki Ono; Ryo Ito; Kaito Arai; Gurdeep Singh (+5 著者) Asuka Inoue
Signal transduction and targeted therapy 8: 307 (2023) Semantic Scholar
11. The present and future of synthetic orexin receptor agonists Saitoh, Tsuyoshi; Sakurai, Takeshi
Peptides 167: (2023) Semantic Scholar
12. Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia Asmaa Elhosainy; Haruka Suzuki-Abe; Mahesh K. Kaushik; Staci J. Kim (+5 著者) Masashi Yanagisawa
European Journal of Pharmacology 175877 - 175877 (2023) Semantic Scholar
13. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Kenta Maeda; Sayaka Ohrui; Akihisa Tokuda; Yasuyuki Nagumo (+4 著者) Hiroshi Nagase
Organic letters 25: 3407 (2023) Semantic Scholar
14. Design and Synthesis of Orexin 1 Receptor-Selective Agonists Iio, Keita; Hashimoto, Kao; Nagumo, Yasuyuki; Amezawa, Mao (+13 著者) Saitoh, Tsuyoshi
Journal of Medicinal Chemistry 66: 5453 (2023) Semantic Scholar
15. Positive allosteric adenosine A_2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice Lin, Yang; Roy, Koustav; Ioka, Shuji; Otani, Rintaro (+9 著者) Lazarus, Michael
Frontiers in pharmacology 14: (2023) Semantic Scholar
16. Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton Amezawa, Mao; Yamamoto, Naoshi; Nagumo, Yasuyuki; Kutsumura, Noriki (+3 著者) Saitoh, Tsuyoshi
Bioorganic & Medicinal Chemistry Letters 82: 129151 (2023) Semantic Scholar
17. オピオイドδ受容体作動薬KNT-127による恐怖記憶の再固定化阻害作用およびその作用部位探索河南絢子; 山田大輔; 吉岡寿倫; 畠山梓摘 (+3 著者) 斎藤顕宜
Proceedings for Annual Meeting of The Japanese Pharmacological Society 97: 3-B-P-089 (2023)
18. Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes Mana Kitano; Tsuyoshi Saitoh; Shigeru Nishiyama; Yasuaki EinagaTakashi Yamamoto
Beilstein Journal of Organic Chemistry 18: 1154 (2022) Semantic Scholar
19. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo (+14 著者) Hiroshi Nagase
European Journal of Medicinal Chemistry 240: 114505 (2022)
20. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
Bioorganic & Medicinal Chemistry Letters 60: 128555 (2022) Semantic Scholar

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1. 日本応用酵素協会誌斉藤, 毅
公益財団法人日本応用酵素協会 2024年3月
2. Diamond Electrodes Fundamentals and Applications Takashi Yamamoto; Tsuyoshi Saitoh (担当:共著, 範囲:Electro-OrganicSynthesis, 177–195)
Springer Nature Singapore Pte Ltd. 2022年 (ISBN: 9789811678332)
3. 有機電解合成の新潮流斉藤毅; 西山繁 (担当:共著, 範囲:第12 章生理活性天然物の電解合成)
シーエムシー出版 2021年11月 (ISBN: 9784781316260)
4. 天然物の化学 II 斉藤, 毅; 長瀬, 博 (担当:分担執筆, 範囲:睡眠覚醒を制御する化学物質)
東京化学同人 2018年7月 (ISBN: 9784807915057)

61. フロー合成を用いた1,3,5-trioxazatriquinane骨格の迅速合成法の開発武田, 翔馬; 須貝, 智也; 斉藤, 毅
第13回サブウェイセミナー
62. フロー合成を用いた1,3,5-trioxazatriquinane骨格の迅速合成法の開発武田, 翔馬; 須貝, 智也; 斉藤, 毅
第85回有機合成化学協会関東支部シンポジウム
63. Development of Highly Productive Synthetic Method for TriMER by Flow System Sugai, Tomoya; Takeda, Shoma; Saito, Tsuyoshi
Flow Chemistry Asia 2023
64. NC114の誘導化を志向した新規合成経路の開発小泉, 優太; 須貝, 智也; 仲矢, 丈雄; 永井, 良三; 長瀬, 博; 斉藤, 毅
日本薬学会第144年会
65. 睡眠の時空間制御を目指した遠隔操作薬の開発斉藤, 毅; Koustav, Roy; 大谷, 凛太朗; 井岡, 秀二; Michael, Lazarus
第18回GPCR研究会
66. 新規モルヒナン型オレキシン1 受容体特異的拮抗薬の創製関谷, 有希; 坂本, 奈津美; 石川, 有紀子; 徳田, 明久; 南雲, 康行; 沓村, 憲樹; 金澤, 奨勝; 塚田, 秀夫; 広川, 貴次; 柳沢, 正史; 長瀬, 博; 斉藤, 毅
第18回GPCR研究会
67. フロー合成を用いた1,3,5-trioxazatriquinane骨格の迅速合成法の開発武田, 翔馬; 須貝, 智也; 斉藤, 毅
第18回GPCR研究会
68. 慢性ストレス誘発うつ・不安様症状に対するδオピオイド受容体作動薬の治療効果及びδオピオイド神経系の機能解析徳田, 明久; 南雲, 康行; 斉藤, 毅; ⻑瀬, 博
第18回GPCR研究会
69. 新規水溶性ブラジキニン2 受容体作動薬の創製新開, 有紗; Gu, Yuzhong; 川上, 耕季; 加藤, 英明; 斉藤, 毅
第18回GPCR研究会
70. Development of remote-control drug toward spatio-temporal regulation of sleep Saito, Tsuyoshi
The 1st KOREA-JAPAN SYMPOSIUM on Chemistry AI for Carbon Neutrality 2024 招待有り
71. Development of Rapid Synthetic Method for 1,3,5-Trioxazatriquinane Skeleton by Using of Continuous Flow Synthesis Sugai, Tomoya; Saito, Tsuyoshi
The 1st KOREA-JAPAN SYMPOSIUM on Chemistry AI for Carbon Neutrality 2024
72. 鎮静作用を分離したκオピオイド受容体作動薬の創製斉藤, 毅
第４２回鎮痛薬・オピオイドペプチドシンポジウム招待有り
73. Re:ゼロから始めるメドケム研究斉藤, 毅
第５６回天然物化学談話会招待有り
74. Chemical reactions promoted by oxygen reduction on boron-doped diamond electrodes Saito, Tsuyoshi
The 10th German- Japanese Meeting on Electrosynthesis 招待有り
75. 三次元配向制御に立脚したオレキシン受容体作動薬の創製斉藤, 毅
日本薬学会第143年会日本薬学会招待有り
76. 鎮静作用を分離したκオピオイド受容体作動薬の創製斉藤, 毅
日本薬学会第143年会日本薬学会招待有り
77. ヘテロビシクロ[2.2.2]オクタン骨格を有する新規κオピオイド受容体作動薬の創製斉藤, 毅
日本薬学会第143年会日本薬学会
78. フロー合成を用いたTriMERの効率的合成法の開発斉藤, 毅
日本薬学会第143年会日本薬学会
79. オレキシン1受容体を介する疼痛制御メカニズムの解析斉藤, 毅
日本薬学会第143年会日本薬学会
80. オレキシン1受容体選択的作動薬の設計と合成斉藤, 毅
日本薬学会第143年会日本薬学会