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斉藤毅

Saito, Tsuyoshi

医学医療系 , 准教授
Institute of Medicine , Associate Professor

https://wpi-iiis.tsukuba.ac.jp/japanese/research/member/detail/tsuyoshisaitoh/

オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。

1. Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity. Kaito Arai; Yuki Ono; Natsumi Hirai; Yuki Sugiura (+7 著者) Asuka Inoue
Biochimica et biophysica acta. Molecular basis of disease 167566 (2024)
2. Tailoring Unstrained Pyrrolidines via Reductive C–N Bond Cleavage with Lewis Acid and Photoredox Catalysis Marina, Hirano; Kazuhiro, Aida; Tsuyoshi, Saitoh; Takashi, Yamamoto (+2 著者) Junichiro, Yamaguchi
ChemRxiv (2024)
3. Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors Koustav Roy; Xuzhao Zhou; Rintaro Otani; Ping-Chuan Yuan (+17 著者) Michael Lazarus
Nature Communications 15: (2024) Semantic Scholar
4. Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor Chiyo Suno-Ikeda; Ryo Nishikawa; Riko Suzuki; Seiya Iwata (+14 著者) Ryoji Suno
bioRxiv (2024) Semantic Scholar
5. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Kenta Maeda; Tomoya Sugai; Akihisa Tokuda; Keita Kajino (+2 著者) Noriki Kutsumura
Bioorganic & medicinal chemistry letters 99: 129611 (2024) Semantic Scholar
6. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology Keita Kajino; Akihisa Tokuda; Tsuyoshi Saitoh
The Journal of Biochemistry (2024)
7. The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala. Ayako Kawaminami; Daisuke Yamada; Toshinori Yoshioka; Azumi Hatakeyama (+4 著者) Akiyoshi Saitoh
Neuropsychopharmacology reports (2023) Semantic Scholar
8. Selective electro-oxidation of cumene utilizing a flow reactor equipped with diamond electrodes Nihongi, Shogo; Matsuoka, Riyako; Saito, Tsuyoshi; Einaga, YasuakiYamamoto, Takashi
Current Research in Green and Sustainable Chemistry 7: 100378 (2023) Semantic Scholar
9. Face validation and pharmacologic analysis of Sik3^Sleepy mutant mouse as a possible model of idiopathic hypersomnia Elhosainy, Asmaa; Suzuki-Abe, Haruka; Kaushik; Mahesh K (+6 著者) Yanagisawa, Masashi
European journal of pharmacology 954: (2023) Semantic Scholar
10. Chemogenetic activation of G12 signaling enhances adipose tissue browning. Yuki Ono; Ryo Ito; Kaito Arai; Gurdeep Singh (+5 著者) Asuka Inoue
Signal transduction and targeted therapy 8: 307 (2023) Semantic Scholar
11. The present and future of synthetic orexin receptor agonists Saitoh, Tsuyoshi; Sakurai, Takeshi
Peptides 167: (2023) Semantic Scholar
12. Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia Asmaa Elhosainy; Haruka Suzuki-Abe; Mahesh K. Kaushik; Staci J. Kim (+5 著者) Masashi Yanagisawa
European Journal of Pharmacology 175877 - 175877 (2023) Semantic Scholar
13. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Kenta Maeda; Sayaka Ohrui; Akihisa Tokuda; Yasuyuki Nagumo (+4 著者) Hiroshi Nagase
Organic letters 25: 3407 (2023) Semantic Scholar
14. Design and Synthesis of Orexin 1 Receptor-Selective Agonists Iio, Keita; Hashimoto, Kao; Nagumo, Yasuyuki; Amezawa, Mao (+13 著者) Saitoh, Tsuyoshi
Journal of Medicinal Chemistry 66: 5453 (2023) Semantic Scholar
15. Positive allosteric adenosine A_2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice Lin, Yang; Roy, Koustav; Ioka, Shuji; Otani, Rintaro (+9 著者) Lazarus, Michael
Frontiers in pharmacology 14: (2023) Semantic Scholar
16. Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton Amezawa, Mao; Yamamoto, Naoshi; Nagumo, Yasuyuki; Kutsumura, Noriki (+3 著者) Saitoh, Tsuyoshi
Bioorganic & Medicinal Chemistry Letters 82: 129151 (2023) Semantic Scholar
17. Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes Mana Kitano; Tsuyoshi Saitoh; Shigeru Nishiyama; Yasuaki EinagaTakashi Yamamoto
Beilstein Journal of Organic Chemistry 18: 1154 (2022) Semantic Scholar
18. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo (+14 著者) Hiroshi Nagase
European Journal of Medicinal Chemistry 240: 114505 (2022)
19. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
Bioorganic & Medicinal Chemistry Letters 60: 128555 (2022) Semantic Scholar
20. Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives. Koki Katoh; Noriki Kutsumura; Naoshi Yamamoto; Yasuyuki Nagumo (+5 著者) Hiroshi Nagase
Bioorganic & Medicinal Chemistry Letters 59: 128550 (2022) Semantic Scholar

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1. 日本応用酵素協会誌斉藤, 毅
公益財団法人日本応用酵素協会 2024年3月
2. Diamond Electrodes Fundamentals and Applications Takashi Yamamoto; Tsuyoshi Saitoh (担当:共著, 範囲:Electro-OrganicSynthesis, 177–195)
Springer Nature Singapore Pte Ltd. 2022年 (ISBN: 9789811678332)
3. 有機電解合成の新潮流斉藤毅; 西山繁 (担当:共著, 範囲:第12 章生理活性天然物の電解合成)
シーエムシー出版 2021年11月 (ISBN: 9784781316260)
4. 天然物の化学 II 斉藤, 毅; 長瀬, 博 (担当:分担執筆, 範囲:睡眠覚醒を制御する化学物質)
東京化学同人 2018年7月 (ISBN: 9784807915057)

101. Design and synthesis of novel κ opioid receptor agonists with bicyclo [2.2.2] octene skeleton 斉藤, 毅
The 11th Annual WPI-IIIS Symposium International Institute for Integrative Sleep Medicine
102. Development of photocaged drugs targeting adenosine 2A receptor 斉藤, 毅
The 11th Annual WPI-IIIS Symposium International Institute for Integrative Sleep Medicine
103. Optochemical control of slow-wave sleep in the nucleus accumbens by a photoactivatable allosteric modulator of adenosine A2A receptors 斉藤, 毅
The 11th Annual WPI-IIIS Symposium International Institute for Integrative Sleep Medicine