ホーム > 南雲 康行/ Nagumo, Yasuyuki

南雲 康行

ALUMNI 2025年9月現在、筑波大学が主たる所属機関ではありません

Nagumo, Yasuyuki

国立研究開発法人国立がん研究センター , がん患者病態生理研究ユニット
National Cancer Center , Cancer Pathophysiology Unit

オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors. Yukari Suda; Keiko Nakamura; Fukiko Matsuyama; Yusuke Hamada (+5 著者) Minoru Narita
      Molecular brain 17: 20 (2024) Semantic Scholar
  2. 2. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Kenta Maeda; Sayaka Ohrui; Akihisa Tokuda; Yasuyuki Nagumo (+4 著者) Hiroshi Nagase
      Organic letters 25: 3407 (2023) Semantic Scholar
  3. 3. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. Keita Iio; Kao Hashimoto; Yasuyuki Nagumo; Mao Amezawa (+13 著者) Tsuyoshi Saitoh
      Journal of medicinal chemistry 66: 5453 (2023) Semantic Scholar
  4. 4. Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement. Kenichi Tanaka; Naoko Kuzumaki; Yusuke Hamada; Yukari Suda (+2 著者) Minoru Narita
      Neurobiology of pain (Cambridge, Mass.) 14: 100133 (2023) Semantic Scholar
  5. 5. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo (+14 著者) Hiroshi Nagase
      European journal of medicinal chemistry 240: 114505 (2022)
  6. 6. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 60: 128555 (2022) Semantic Scholar
  7. 7. Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives. Koki Katoh; Noriki Kutsumura; Naoshi Yamamoto; Yasuyuki Nagumo (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128550 (2022) Semantic Scholar
  8. 8.

    Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring

         Keita Iio; Tsuyoshi Saitoh; Ryuichiro Ohshita; Tsubasa Hino (+9 著者) Hiroshi Nagase
      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 60: (2022) Semantic Scholar
  9. 9. Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors. Koki Katoh; Naoshi Yamamoto; Yukiko Ishikawa; Yoko Irukayama-Tomobe (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128527 (2022) Semantic Scholar
  10. 10. Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton. Tsubasa Hino; Tsuyoshi Saitoh; Yasuyuki Nagumo; Naoshi Yamamoto (+5 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 59: 128530 (2022)
  11. 11. Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands. Keita Iio; Noriki Kutsumura; Yasuyuki Nagumo; Tsuyoshi Saitoh (+6 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 56: 128485 (2022) Semantic Scholar
  12. 12. OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy. Hikari Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama-Tomobe (+8 著者) Masashi Yanagisawa
      PloS one 17: e0271901 (2022) Semantic Scholar
  13. 13. Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives Tsubasa Hino; Noriki Kutsumura; Tsuyoshi Saitoh; Naoshi Yamamoto (+3 著者) Hiroshi Nagase
      TETRAHEDRON LETTERS 63: (2021) Semantic Scholar
  14. 14. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine. Yasuyuki Nagumo; Koki Katoh; Keita Iio; Tsuyoshi Saitoh (+8 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 30: 127360 (2020) Semantic Scholar
  15. 15. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine (in press) Yasuyuki Nagumo; Koki Katoh; Keita Iio; Tsuyoshi Saitoh (+8 著者) Hiroshi Nagase
      (2020)
  16. 16. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations Yasuyuki Nagumo; Yoshifumi Ueta; Hisako Nakayama; Hironobu Osaki (+3 著者) Mariko Miyata
      Cell Reports 31: 107797 (2020) Semantic Scholar
  17. 17. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities Noriki Kutsumura; Yasuaki Koyama; Tsuyoshi Saitoh; Naoshi Yamamoto (+7 著者) Hiroshi Nagase
      Molecules (2020) Semantic Scholar
  18. 18. Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. Tsuyoshi Saitoh; Kazunori Seki; Ryo Nakajima; Naoshi Yamamoto (+6 著者) Hiroshi Nagase
      Bioorganic & medicinal chemistry letters 30: 126893 (2020) Semantic Scholar
  19. 19. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Saitoh T; Seki K; Nakajima R; Yamamoto N (+7 著者) Nagase H
      Bioorganic & medicinal chemistry letters 29: 2655 (2019) Semantic Scholar
  20. 20. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity Saitoh, Tsuyoshi; Seki, Kazunori; Nakajima, Ryo; Yamamoto, Naoshi (+7 著者) Nagase, Hiroshi
      Bioorganic & medicinal chemistry letters 29: 2655 (2019) Semantic Scholar
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  1. 1. トワイクロス先生のがん緩和ケア処方薬 : 薬効・薬理と薬の使い方 監訳; 武田文和; 鈴木 勉; 共著パート翻訳; 南雲康行 (担当:分担執筆, 範囲:抗てんかん薬)
    医学書院 2013年 (ISBN: 9784260015219)

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