ホーム > 小久保 利雄/ Kokubo, Toshio

小久保 利雄

ALUMNI 2025年3月現在、筑波大学が主たる所属機関ではありません

Kokubo, Toshio

国際統合睡眠医科学研究機構 , 教授
International Institute for Integrative Sleep Medicine , Professor
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  1. 1. Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial Zhang, Simeng; Takano, Jiro; Murayama, Norihito; Tominaga, Morie (+11 著者) Tokuyama, Kumpei
      Nutrients 12: 3671 (2020) Semantic Scholar
  2. 2. Improvement of slow wave sleep continuity by mattress with better body pressure dispersal. Kokubo, Toshio; Kayaba, M; Ogata, H; Park, I (+6 著者) Satoh, M
      Sleep Medicine Research 10: 75 (2019) Semantic Scholar
  3. 3. DIFFERENT EFFECTS OF OREXIN RECEPTOR ANTAGONIST AND GABA(A) AGONIST ON PHYSICAL AND COGNITIVE FUNCTIONS AFTER FORCED AWAKENING Seol, J; Fujii, Y; Park, I; Yoko, S (+7 著者) Yanagisawa, M
      SLEEP MEDICINE 64: S343 (2019)
  4. 4. Distinct effects of orexin receptor antagonist and GABA agonist on sleep and physical/cognitive functions after forced awakening Seol, Jaehoon; Fujii, Yuya; Park, Insung; Suzuki, Yoko (+7 著者) Yanagisawa, Masashi
      Proceedings of the National Academy of Sciences of the United States of America 116: 24353 (2019) Semantic Scholar
  5. 5. Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey Oshima, Tsutomu; Miyashita, Hideaki; Ishimura, Yoshimasa; Ito, Yuki (+4 著者) Tomofumi
      PLOS ONE 13: (2018) Semantic Scholar
  6. 6. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers Oshima, Tsutomu; Sato, Shuji; Kato, Junichi; Ito, Yuki (+4 著者) Kokubo, Toshio
      Molecular cancer 12: 60 (2013) Semantic Scholar
  7. 7. A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells Nakashima, Kosuke; Kokubo, Toshio; Shichijo, Michitaka; Li, Ying-Fu (+1 著者) Yamamoto, Noriyuki
      European journal of pharmacology 505: 223 (2004)
  8. 8. Inhibition of syk activity and degranulation of human mast cells by flavonoids Shichijo, Michitaka; Yamamoto, Noriyuki; Tsujishita, Hideki; Kimata, Masahiro (+1 著者) Kokubo, Toshio
      Biological & pharmaceutical bulletin 26: 1685 (2003) Semantic Scholar
  9. 9. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents Yamamoto, Noriyuki; Takeshita, Keisuke; Shichijo, Michitaka; Kokubo, Toshio (+6 著者) Bacon, Kevin B
      The Journal of pharmacology and experimental therapeutics 306: 1174 (2003)
  10. 10. Establishment of the superoxide production assay with human monocytic cell line, U937, for the evaluation of Syk kinase inhibitors Yamamoto, Noriyuki; Shichijo, Michitaka; Kokubo, Toshio
      Journal of immunological methods 268: 123 (2002)
  11. 11. Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR Ishibashi, O; Inui, T; Mori, Y; Kurokawa, T (+1 著者) Kumegawa, M
      Calcified tissue international 68: 109 (2001)
  12. 12. New immunosuppressive reagent, FTY 720, spares immunologic memory Lei, G; Amemiya, H; Suzuki, S; Goto, T (+2 著者) Kimura, H
      Transplantation proceedings 32: 1628 (2000)
  13. 13. Cytokine requirement for the development of rat dendritic cells by in vitro culturing of bone marrow cells Hua, Y; Miyagi, T; Saito, H; Gold, D P (+6 著者) Kimura, H
      Transplantation proceedings 32: 2078 (2000)
  14. 14. Microchimerism and allograft acceptance: is it caused by microchimerism or graft antigens? Kimura, H; Hua, Y; Goto, T; Kokubo, T (+3 著者) Tanaka, K
      Transplantation proceedings 32: 2045 (2000)
  15. 15. Directed evolution to improve the thermostability of prolyl endopeptidase Uchiyama, H; Inaoka, T; Ohkuma-Soyejima, T; Togame, H (+2 著者) Kokubo, T
      Journal of biochemistry 128: 441 (2000)
  16. 16. Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin Aita, T; Uchiyama, H; Inaoka, T; Nakajima, M (+1 著者) Husimi, Y
      Biopolymers 54: 64 (2000)
  17. 17. Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action Inui, T; Ishibashi, O; Origane, Y; Fujimori, K (+1 著者) Nakajima, M
      Biochemical and biophysical research communications 258: 173 (1999)
  18. 18. Conformational studies on the specific cleavage site of Type I collagen (alpha-1) fragment (157-192) by cathepsins K and L by proton NMR spectroscopy Nosaka, A Y; Kanaori, K; Teno, N; Togame, H (+2 著者) Kokubo, T
      Bioorganic & medicinal chemistry 7: 375 (1999) Semantic Scholar
  19. 19. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma Littlewood-Evans, A J; Bilbe, G; Bowler, W B; Farley, D (+5 著者) Gallagher, J A
      Cancer research 57: 5386 (1997)
  20. 20. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption Inui, T; Ishibashi, O; Inaoka, T; Origane, Y (+2 著者) Yamamura, T
      The Journal of biological chemistry 272: 8109 (1997)
1 2
  1. 1. Molecular and Cellular Biology of Bone Kokubo, Toshio; Ishibashi, O; Kumegawa, M (担当:分担執筆, 範囲:Role of proteases in osteoclastic resorption.)
    JAI Press 1998年
  2. 2. Development of Some Reactions Controlled in Molecular Assemblies Kokubo,Toshio
    1983年5月
  1. 1. Different effects of orexin receptor antagonist and GABAa agonist on physical and cognitive functions Seol, J; Fujii, Y; Park, I; Suzuki, Y; Kawana, F; Fukusumi, S; OKURA, Tomohiro; Satoh, M; Tokuyama, K; Kokubo, T; Yanagisawa, M
    The 7th Annual IIIS Symposium 2018年12月

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