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吉野 龍ノ介

Yoshino, Ryunosuke

医学医療系 , 助教
Institute of Medicine , Assistant Professor

ゼロからの創薬では遅すぎる！ スパコンの仮想生化学実験で、効く薬の候補を高速発見
Drug discovery from scratch is too late Identifying potential candidates faster through virtual biochemical experiments using supercomputers

2020-09-04

重田 育照 吉野 龍ノ介 原田 隆平
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Effects of chemosynthetic choline plasmalogens on gonadotropin secretion from bovine gonadotrophs Kadokawa, Hiroya; Niyonzima; Yvan Bienvenu; Hirokawa, TakatsuguYoshino, Ryunosuke
      The Journal of reproduction and development 71: 201 (2025)
  2. 2. CrypToth: Cryptic Pocket Detection through Mixed-Solvent Molecular Dynamics Simulations-Based Topological Data Analysis Koseki, Jun; Motono, Chie; Yanagisawa, Keisuke; Kudo, Genki (+2 著者) Imai, Kenichiro
      JOURNAL OF CHEMICAL INFORMATION AND MODELING (2025)
  3. 3. Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation. Genki Kudo; Takumi Hirao; Ryuhei Harada; Takatsugu Hirokawa (+1 著者) Ryunosuke Yoshino
      Scientific reports 14: 13508 (2024) Semantic Scholar
  4. 4. Site Identification and Next Choice Protocol for Hit-to-Lead Optimization Kudo, Genki; Hirao, Takumi; Yoshino, Ryunosuke; Shigeta, Yasuteru (+1 著者) Takatsugu
      JOURNAL OF CHEMICAL INFORMATION AND MODELING 64: 4475 (2024) Semantic Scholar
  5. 5. AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics Kudo, Genki; Yanagisawa, Keisuke; Yoshino, Ryunosuke; HirokawaTakatsugu
      JOURNAL OF CHEMICAL INFORMATION AND MODELING 63: 7768 (2023) Semantic Scholar
  6. 6. Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography Ryunosuke Yoshino; Nobuaki Yasuo; Yohsuke Hagiwara; Takashi Ishida (+9 著者) Masakazu Sekijima
      ACS Omega (2023) Semantic Scholar
  7. 7. Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity Saito, Kenji; Sekiya, Motohiro; Kainoh, Kenta; Yoshino, Ryunosuke (+21 著者) Shimano, Hitoshi
      J Biol Chem 299: 104890 (2023) Semantic Scholar
  8. 8. Pocket to concavity: a tool for the refinement of protein-ligand binding site shape from alpha spheres Kudo, Genki; Hirao, Takumi; Yoshino, Ryunosuke; Shigeta, Yasuteru (+1 著者) Takatsugu
      BIOINFORMATICS 39: (2023) Semantic Scholar
  9. 9. Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis. Junya Tabata; Takashi Nakaoku; Mitsugu Araki; Ryunosuke Yoshino (+13 著者) Takashi Kohno
      Cancer research 82: 3751 (2022) Semantic Scholar
  10. 10. A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin. Miho Watanabe-Takahashi; Miki Senda; Ryunosuke Yoshino; Masahiro Hibino (+4 著者) Kiyotaka Nishikawa
      Scientific reports 12: 11443 (2022) Semantic Scholar
  11. 11. Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist. Hiroya Kadokawa; Ryunosuke Yoshino; Risa Saito; Takatsugu Hirokawa
      Animal reproduction science 241: 106992 (2022) Semantic Scholar
  12. 12. Inverse Mixed-Solvent Molecular Dynamics for Visualization of the Residue Interaction Profile of Molecular Probes. Keisuke Yanagisawa; Ryunosuke Yoshino; Genki Kudo; Takatsugu Hirokawa
      International journal of molecular sciences 23: (2022) Semantic Scholar
  13. 13. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. Kazue Inaba; Kana Ebihara; Miki Senda; Ryunosuke Yoshino (+20 著者) Ryusuke Niwa
      BMC biology 20: 43 (2022) Semantic Scholar
  14. 14. The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. Motohiro Sekiya; Kenta Kainoh; Takehito Sugasawa; Ryunosuke Yoshino (+8 著者) Hitoshi Shimano
      Nature communications 12: 6315 (2021) Semantic Scholar
  15. 15. Integrate in silico studies on the role of nicotinamide adenine dinucleotide (NADH) binding in activating C-terminal binding protein 2 (CtBP2) Tsukasa, Aoyagi; Yoshino, Ryunosuke; Yuki, Mitsuta; Rikuri, Morita (+1 著者) Yasuteru, Shigeta
      Chemistry Letters 51: 1 (2021) Semantic Scholar
  16. 16. Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo. Kotaro Koiwai; Kana Morohashi; Kazue Inaba; Kana Ebihara (+9 著者) Ryusuke Niwa
      Journal of pesticide science 46: 75 (2021) Semantic Scholar
  17. 17. Identification of key interactions between SARS-CoV-2 main protease and inhibitor drug candidates. Ryunosuke Yoshino; Nobuaki Yasuo; Masakazu Sekijima
      Scientific reports 10: 12493 (2020) Semantic Scholar
  18. 18. An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo. Kotaro Koiwai; Kazue Inaba; Kana Morohashi; Sora Enya (+13 著者) Ryusuke Niwa
      The Journal of biological chemistry 295: 7154 (2020) Semantic Scholar
  19. 19. A prospective compound screening contest identified broader inhibitors for Sirtuin 1. Shuntaro Chiba; Masahito Ohue; Anastasiia Gryniukova; Petro Borysko (+48 著者) Masakazu Sekijima
      Scientific reports 9: 19585 (2019) Semantic Scholar
  20. 20. Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil. Ryunosuke Yoshino; Nobuaki Yasuo; Masakazu Sekijima
      Scientific reports 9: 17464 (2019) Semantic Scholar
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書籍等出版物情報はまだありません。

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