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原田 隆平

Harada, Ryuhei

計算科学研究センター , 准教授
Center for Computational Sciences

リボソーム内の化学的性質が翻訳中のタンパク質の立体構造に影響する

2024-08-20

原田 隆平
UBE学術振興財団第64回学術奨励賞

2024-04-01

原田 隆平
Bulletin of the Chemical Society of Japan 優秀論文

2023-07-24

原田 隆平 HENGPHASATPORN KOWIT 重田 育照
【受賞】原田准教授が第 50 回 構造活性相関シンポジウムSAR Presentation Awardを受賞

2022-11-10

原田 隆平 重田 育照
タンパク質の構造変化と生命機能の関係の解明 | 重田 育照 | 筑波大学研究者カタログ

2021-04-12

重田 育照 庄司 光男 原田 隆平 西澤 宏晃 堀 優太 原嶋 庸介
スーパーコンピュータを活用して「効く薬の候補」を素早く見つけ出す | 重田 育照

2021-04-01

重田 育照 広川 貴次 原田 隆平
ゼロからの創薬では遅すぎる！ スパコンの仮想生化学実験で、効く薬の候補を高速発見
Drug discovery from scratch is too late Identifying potential candidates faster through virtual biochemical experiments using supercomputers

2020-09-04

重田 育照 吉野 龍ノ介 原田 隆平
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Striatal Type I Interferon Responses Drive Disease Progression in the Amyotrophic Lateral Sclerosis Shogo Tanabe, Keisuke Sekine, Koryo Obata, Terunori Sano, Akiko Uyeda, Lili Quan, Masaki Ueno, Ryuhei Harada, Koji Okamoto, Masaki Takao, Rieko Muramatsu
      Science, submitted (2025)
  2. 2. Chemical Diversity within Chaperonins Contributes to Stabilizing Substrate Protein Configurations Takunori Yasuda; Yoshino Okamoto; Yasuteru Shigeta; Ryuhei Harada
      The Journal of Physical Chemistry Letter, 16: 6321 (2025)
  3. 3. Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search Genki Kudo; Takumi Hirao; Ryuhei Harada; Yasuteru Shigeta (+1 著者) Ryunosuke Yoshino
      Journal of Chemical Information and Modeling 65: 6939 (2025)
  4. 4. Rational Designed and Engineered Antimicrobial Peptides with High Selectivity and Efficiency Against Phytopathogenic Ralstonia Solanecearum Melvalia Cristin Manik; Kikrusenuo Kiewhuo; Thanyada Rungrotmongkol; Lian Duan (+4 著者) Alisa Vangnai
      Science of the Total Environment 976: 179354 (2025)
  5. 5. In Silico Study on the Intrusion Process of an Inhibitor into AQP7 Channel Toward Efficient Drug Design Koryo Obata; Yasuteru Shigeta; Ryuhei Harada
      Chemistry Letters 54: upaf063 (2025)
  6. 6. PaCS-Q: Enhanced Sampling Techniques in QM/MM Molecular Dynamics Simulations Lian Duan; Kowit Hengphasatporn; Ryuhei Harada; Yasuteru Shigeta
      Journal of Chemical Theory and Computation, 21: 4309 (2025)
  7. 7. Plug-and-Play Toolkit for Ligand-Binding Path Sampling Parallel Cascade Selection Molecular Dynamics Simulation for AMBER and GROMACS Ryuhei Harada; Kowit Hengphasatporn; Yasuteru Shigeta
      (2025)
  8. 8. Characterization of Delta-7 Alkenone Desaturase in Haptophytes Emiliania Huxleyi Through the Heterologous Expression in Tisochrysis Lutea Kohei Yoneda; Chinatsu Kobayashi; Hiroya Araie; Rikuri Morita (+4 著者) Iwane Suzuki
      Marine Biotechnology 27: 1 (2025)
  9. 9. Unveiling the Antiviral Inhibitory Activity of Ebselen and Ebsulfur Derivatives on SARS-CoV-2 Using Machine Learning-based QSAR, LB-PaCS-MD, and Experimental Assay Silpsiri Sinsulpsiri; Yuji Nishii; Qing-Feng Xu-Xu; Masahiro Miura (+12 著者) Thanyada Rungrotmongkol
      Scientific Report 15: 6956 (2025)
  10. 10. Phosphorylation on the N-terminal in Hmt1 Enhances Dimerization by Exposing the Binding Surface Miyabi Endo; Takunori Yasuda; Rikuri Morita; Tomoaki Mizuno (+1 著者) Ryuhei Harada
      Proteins: Structure, Function, and Bioinformatics, Manuscript Prot-00427-2024, under review: (2025)
  11. 11. The Behavior of Water in Superheated Liquid Phase Observed in Molecular Dynamics Simulation Morita Rikuri; Yasuteru Shigeta; Ryuhei Harada
      Chemistry Letters, Manuscript ID CL-240416, under review: (2024)
  12. 12. BEMM-GEN: A Tool for Generating a Biomolecular Environment Mimicking Model for Molecular Dynamics Simulation Takunori Yasuda; Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Journal of Chemical Information and Modeling 64: 7184 (2024)
  13. 13. Structural Fluctuation in Homodimeric Aminoacyl-tRNA Synthetases Induces Half-of-the-sites Activity Yoshino Okamoto; Takunori Yasuda; Rikuri Morita; Yasuteru ShigetaRyuhei Harada
      The Journal of Physical Chemistry B 128: 10823 (2024)
  14. 14. Evaluating Solubility, Stability, and Inclusion Complexation of Oxyresveratrol with Various β-cyclodextrin Derivatives Using Advanced Computational Techniques and Experimental Validation Saba Ali; Aamir Aman; Kowit Hengphasatporn; Ryo Fujiki (+7 著者) Thanyada Rungrotmongkol
      Computational Biology and Chemistry, 112: 108111 (2024)
  15. 15. CommunicationMachine Learning-Based QSAR and LB-PaCS-MD Guided Design of SARS-CoV-2 Main Protease Inhibitors Borwornlak Toopradab; Wanting Xie; Lian Duan; Kowit Hengphasatporn (+5 著者) Thanyada Rungrotmongkol
      Bioorganic & Medicinal Chemistry Letters 110: 129852 (2024)
  16. 16. Ribosome Tunnel Environment Drives the Formation of α-Helix During Co-Translational Folding Takunori Yasuda; Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Journal of Chemical Information and Modeling 64: 6610 (2024) Semantic Scholar
  17. 17. Structural Generation by Inverse Transformation Using Principal Component Analysis Enhances Conformational Sampling of Protein Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Bulletin of the Chemical Society of Japan 97: uoae087 (2024)
  18. 18. Prediction of the Binding Mechanism of a Selective DNA Methyltransferase 3A Inhibitor by Molecular Simulation Genki Kudo; Takumi Hirao; Ryuhei Harada; Takatsugu Hirokawa (+1 著者) Ryunosuke Yoshino
      Scientific Report 14: 13508 (2024)
  19. 19. Alpha and Gamma Mangostins Inhibit Wild-type B SARS-CoV-2 More Effectively than the SARS-CoV-2 Variants and the Major Target is Unlikely a 3C-like Protease Aphinya Suroengri; Van Cao; Patcharin Wilasluck; Peerapon Deetanya (+11 著者) Siwaporn Boonyasuppayakorn
      Heliyon 10: e31987 (2024)
  20. 20. Development of Membrane Permeability Coefficient by Means of Novel Molecular Dynamics Methods Ryuhei Harada; Yuki Mitsuta; Yasuteru Shigeta
      YAKUGAKU ZASSHI 144: 545 (2024)
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書籍等出版物情報はまだありません。

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