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原田 隆平

Harada, Ryuhei

計算科学研究センター , 准教授

リボソーム内の化学的性質が翻訳中のタンパク質の立体構造に影響する

2024-08-20

原田 隆平
UBE学術振興財団第64回学術奨励賞

2024-04-01

原田 隆平
Bulletin of the Chemical Society of Japan 優秀論文

2023-07-24

原田 隆平 HENGPHASATPORN KOWIT 重田 育照
【受賞】原田准教授が第 50 回 構造活性相関シンポジウムSAR Presentation Awardを受賞

2022-11-10

原田 隆平 重田 育照
タンパク質の構造変化と生命機能の関係の解明 | 重田 育照 | 筑波大学研究者カタログ

2021-04-12

重田 育照 庄司 光男 原田 隆平 西澤 宏晃 堀 優太 原嶋 庸介
スーパーコンピュータを活用して「効く薬の候補」を素早く見つけ出す | 重田 育照

2021-04-01

重田 育照 広川 貴次 原田 隆平
ゼロからの創薬では遅すぎる！ スパコンの仮想生化学実験で、効く薬の候補を高速発見
Drug discovery from scratch is too late Identifying potential candidates faster through virtual biochemical experiments using supercomputers

2020-09-04

重田 育照 吉野 龍ノ介 原田 隆平
オープンアクセス版の論文は「つくばリポジトリ」で読むことができます。
  1. 1. Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search Genki Kudo; Takumi Hirao; Ryuhei Harada; Yasuteru Shigeta (+1 著者) Ryunosuke Yoshino
      Journal of Chemical Information and Modeling, DOI: 10.1021/acs.jcim.5c00102, in press: (2025)
  2. 2. Chemical Diversity within Chaperonins Contributes to Stabilizing Substrate Protein Configurations Takunori Yasuda; Yoshino Okamoto; Yasuteru Shigeta; Ryuhei Harada
      The Journal of Physical Chemistry Letter, 16: 6321 (2025)
  3. 3. Rational Designed and Engineered Antimicrobial Peptides with High Selectivity and Efficiency Against Phytopathogenic Ralstonia Solanecearum Melvalia Cristin Manik; Kikrusenuo Kiewhuo; Thanyada Rungrotmongkol; Lian Duan (+4 著者) Alisa Vangnai
      Science of the Total Environment 976: 179354 (2025)
  4. 4. In Silico Study on the Intrusion Process of an Inhibitor into AQP7 Channel Toward Efficient Drug Design Koryo Obata; Yasuteru Shigeta; Ryuhei Harada
      Chemistry Letters 54: upaf063 (2025)
  5. 5. PaCS-Q: Enhanced Sampling Techniques in QM/MM Molecular Dynamics Simulations Lian Duan; Kowit Hengphasatporn; Ryuhei Harada; Yasuteru Shigeta
      Journal of Chemical Theory and Computation, 21: 4309 (2025)
  6. 6. Plug-and-Play Toolkit for Ligand-Binding Path Sampling Parallel Cascade Selection Molecular Dynamics Simulation for AMBER and GROMACS Ryuhei Harada; Kowit Hengphasatporn; Yasuteru Shigeta
      (2025)
  7. 7. Characterization of Delta-7 Alkenone Desaturase in Haptophytes Emiliania Huxleyi Through the Heterologous Expression in Tisochrysis Lutea Kohei Yoneda; Chinatsu Kobayashi; Hiroya Araie; Rikuri Morita (+4 著者) Iwane Suzuki
      Marine Biotechnology 27: 1 (2025)
  8. 8. Unveiling the Antiviral Inhibitory Activity of Ebselen and Ebsulfur Derivatives on SARS-CoV-2 Using Machine Learning-based QSAR, LB-PaCS-MD, and Experimental Assay Silpsiri Sinsulpsiri; Yuji Nishii; Qing-Feng Xu-Xu; Masahiro Miura (+12 著者) Thanyada Rungrotmongkol
      Scientific Report 15: 6956 (2025)
  9. 9. Phosphorylation on the N-terminal in Hmt1 Enhances Dimerization by Exposing the Binding Surface Miyabi Endo; Takunori Yasuda; Rikuri Morita; Tomoaki Mizuno (+1 著者) Ryuhei Harada
      Proteins: Structure, Function, and Bioinformatics, Manuscript Prot-00427-2024, under review: (2025)
  10. 10. The Behavior of Water in Superheated Liquid Phase Observed in Molecular Dynamics Simulation Morita Rikuri; Yasuteru Shigeta; Ryuhei Harada
      Chemistry Letters, Manuscript ID CL-240416, under review: (2024)
  11. 11. BEMM-GEN: A Tool for Generating a Biomolecular Environment Mimicking Model for Molecular Dynamics Simulation Takunori Yasuda; Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Journal of Chemical Information and Modeling 64: 7184 (2024)
  12. 12. Structural Fluctuation in Homodimeric Aminoacyl-tRNA Synthetases Induces Half-of-the-sites Activity Yoshino Okamoto; Takunori Yasuda; Rikuri Morita; Yasuteru ShigetaRyuhei Harada
      The Journal of Physical Chemistry B 128: 10823 (2024)
  13. 13. Evaluating Solubility, Stability, and Inclusion Complexation of Oxyresveratrol with Various β-cyclodextrin Derivatives Using Advanced Computational Techniques and Experimental Validation Saba Ali; Aamir Aman; Kowit Hengphasatporn; Ryo Fujiki (+7 著者) Thanyada Rungrotmongkol
      Computational Biology and Chemistry, 112: 108111 (2024)
  14. 14. CommunicationMachine Learning-Based QSAR and LB-PaCS-MD Guided Design of SARS-CoV-2 Main Protease Inhibitors Borwornlak Toopradab; Wanting Xie; Lian Duan; Kowit Hengphasatporn (+5 著者) Thanyada Rungrotmongkol
      Bioorganic & Medicinal Chemistry Letters 110: 129852 (2024)
  15. 15. Structural Generation by Inverse Transformation Using Principal Component Analysis Enhances Conformational Sampling of Protein Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Bulletin of the Chemical Society of Japan 97: uoae087 (2024)
  16. 16. Ribosome Tunnel Environment Drives the Formation of α-Helix During Co-Translational Folding Takunori Yasuda; Rikuri Morita; Yasuteru Shigeta; Ryuhei Harada
      Journal of Chemical Information and Modeling 64: 6610 (2024) Semantic Scholar
  17. 17. Prediction of the Binding Mechanism of a Selective DNA Methyltransferase 3A Inhibitor by Molecular Simulation Genki Kudo; Takumi Hirao; Ryuhei Harada; Takatsugu Hirokawa (+1 著者) Ryunosuke Yoshino
      Scientific Report 14: 13508 (2024)
  18. 18. Alpha and Gamma Mangostins Inhibit Wild-type B SARS-CoV-2 More Effectively than the SARS-CoV-2 Variants and the Major Target is Unlikely a 3C-like Protease Aphinya Suroengri; Van Cao; Patcharin Wilasluck; Peerapon Deetanya (+11 著者) Siwaporn Boonyasuppayakorn
      Heliyon 10: e31987 (2024)
  19. 19. Development of Membrane Permeability Coefficient by Means of Novel Molecular Dynamics Methods Ryuhei Harada; Yuki Mitsuta; Yasuteru Shigeta
      YAKUGAKU ZASSHI 144: 545 (2024)
  20. 20. Preferential Door for Ligand Binding and Unbinding Pathways in Inhibited Human Acetylcholinesterase Nalinee Kongkaew; Kowit Hengphasatporn; Yasuteru Shigeta; Thanyada RungrotmongkolRyuhei Harada
      The Journal of Physical Chemistry Letters 15: 5696 (2024)
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書籍等出版物情報はまだありません。

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